Learn More
Over the last twenty years, the open source community has provided more and more software on which the world's High Performance Computing (HPC) systems depend for performance and productivity. The community has invested millions of dollars and years of effort to build key components. But although the investments in these separate software elements have been(More)
Introduction. Classical opioid receptors (µ, δ, and κ) have important physiological and pharmacological roles, especially in pain regulation. A fourth opioid receptor, opioid receptor-like 1 (ORL1), was identified in 1994 through cDNA expression cloning techniques. 1 ORL1 is a member of the G-protein coupled receptor superfamily with a high degree of amino(More)
Nondeterministic nature of parallel programs is the major difficulty in debugging. Order-replay, a technique to solve this problem, is widely used because of its small overhead. It has, however, several serious drawbacks: all processes of the parallel program have to participate in replay even when some of them are clearly not involved with the bug; and the(More)
In order to reduce the overhead of synchronizing operations of shared memory multiprocessors, this paper proposes a mechanism, named specMEM, to execute memory accesses following a synchronizing operation speculatively before the completion of the synchronization is conrmed. A unique feature of our mechanism is that the detection of speculation failure and(More)
The tropical zebrafish (Danio rerio) has frequently been used for investigating developmental biology. Here, we developed a computer image processing system for quantifying zebrafish behavior. We could acquire an image of zebrafish freely moving in an aquarium using a CCD camera through a graphic I/O board. To acquire the image of moving zebrafish in real(More)
ABCG2, also known as BCRP, is a high-capacity urate exporter, the dysfunction of which raises gout/hyperuricemia risk. Generally, hyperuricemia has been classified into urate 'overproduction type' and/or 'underexcretion type' based solely on renal urate excretion, without considering an extra-renal pathway. Here we show that decreased extra-renal urate(More)
Unlike mammals, fish motor function can recover within 6-8weeks after spinal cord injury (SCI). The motor function of zebrafish is regulated by dual control; the upper motor neurons of the brainstem and motor neurons of the spinal cord. In this study, we aimed to investigate the framework behind the regeneration of upper motor neurons in adult zebrafish(More)
Gout is a common disease which mostly occurs after middle age, but more people nowadays develop it before the age of thirty. We investigated whether common dysfunction of ABCG2, a high-capacity urate transporter which regulates serum uric acid levels, causes early-onset gout. 705 Japanese male gout cases with onset age data and 1,887 male controls were(More)
The hedgehog (Hh) signaling pathway, which functions as an organizer in embryonic development, is implicated in the development of various tumors. In pancreatic cancer, pathway activation is reported to result from aberrant expression of the ligand, sonic Hh (Shh). However, the details of the mechanisms regulating Shh expression are not yet known. We(More)