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Photoreceptive, melanopsin-expressing retinal ganglion cells (mRGCs) encode ambient light (irradiance) for the circadian clock, the pupillomotor system, and other influential behavioral/physiological responses. mRGCs are activated both by their intrinsic phototransduction cascade and by the rods and cones. However, the individual contribution of each(More)
Serum stimulation of a number of different mouse cell lines results in sustained oscillations of Hes1, a member of this Hes/Her family of transcription factors. Quantitative time-course expression data obtained in this system provide an excellent opportunity to explore transcriptional oscillations in a relatively simple setting. Simple models of the Hes1(More)
Lateral inhibition resulting from a double-negative feedback loop underlies the assignment of different fates to cells in many developmental processes. Previous studies have shown that the presence of time delays in models of lateral inhibition can result in significant oscillatory transients before patterned steady states are reached. We study the impact(More)
Oscillatory expression of the Hes family of transcription factors plays a central role in the segmentation of the vertebrate body during embryonic development. Analogous oscillations in cultured cells suggest that Hes oscillations may be important in other developmental processes, and provide an excellent opportunity to explore the origin of these(More)
A mathematical formulation is developed to model the dynamics of sand dunes. The physical processes display strong non-linearity that has been taken into account in the model. When assessing the success of such a model in capturing physical features we monitor morphology, dune growth, dune migration and spatial patterns within a dune field. Following recent(More)
A cellular model of the primate retina has been developed. Unlike existing models, it incorporates spatial non-uniformities, such as the random arrangement of L and M cones, and the radial dilation with eccentricity. Based on a population of ganglion cell activities, colour-image representation is modelled with the luminance and the R-G opponent channels.(More)
It remains an important question whether neural function is mediated entirely by its tailored circuitry. A persistent debate in retinal colour vision is whether the centre and the surround of a ganglion cell receptive field receive dominant inputs either from L or M cones in an antagonistic manner (the selective wiring model) or mixed inputs (the mixed(More)
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