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BACKGROUND S-1 is an oral fluoropyrimidine whose antitumor effects have been demonstrated in treating various gastrointestinal cancers, including metastatic colon cancer, when administered as monotherapy or in combination chemotherapy. We conducted a randomized phase III study investigating the efficacy of S-1 as adjuvant chemotherapy for colon cancer by(More)
We report on two Japanese brothers with hereditary deficiency in γ-glutamyl transpeptidase. The propositus was 48 years old when he first visited our medical center and had a 51-year-old brother. The brothers were both tall and slender and had long limbs; the younger was diagnosed as having Marfan syndrome. Both patients both showed a tendency to retarded(More)
Sirs, We have read with great interest the articles in this journal by Chiu [1] and Bircan [2] regarding poststreptococcal glomerulonephritis with pulmonary edema. Chiu et al. [1] described six school-age children with acute poststreptococcal glomerulonephritis (APSGN) and pulmonary edema which initially were misinterpreted as pneumonia. Similarly, Bircan(More)
The optic-spinal form of multiple sclerosis (OSMS), characterized by recurrent involvement of optic nerve and spinal cord with rare brain magnetic resonance imaging lesions, is relatively common among Asians. While individual cases of OSMS with anti-thyroid autoantibodies (ATABs) have been reported, the frequency of ATAbs in OSMS and classical multiple(More)
Although diffuse crescentic formation in immunoglobulin A (IgA) nephropathy, histologically characterized by extensive extracapillary proliferation, is assumed to have a poor prognosis, there has still been no established treatment because of the low prevalence of the condition, especially in pediatric patients. This paper reports on a 5-year-old boy with(More)
We report two patients of status epilepticus, in which detailed brain magnetic resonance image (MRI) studies were performed. In one patient apparent diffusion coefficient (ADC) increased in the right temporopareital regions in the acute phase. This patient finally has good clinical course without neurological deficits, and abnormal findings on MRI also(More)
Sirs: A 49-year-old Japanese woman had suffered from gait disturbance since 1990 and memory disturbance since 1994. She visited Miyagi National Hospital in 1995, where she was found to have bradykinesia, muscle rigidity of the neck and extremities without laterality, retro-pulsion, dementia, delusion, and visual hallucinations. Tremor and fluctuation in(More)
The findings on computed tomography (CT) and neuropathological examinations were correlated in 87 autopsied cases of cerebrovascular disease with regard to the size and location of lesions, experience of reviewers, and improvement in CT quality. Small infarctions less than 5 mm were very difficult to detect accurately on CT. This was largely because of the(More)
BACKGROUND Large clinical trials are lack of data on non-vitamin K antagonist oral anticoagulants for acute stroke patients. AIM To evaluate the choice of oral anticoagulants at acute hospital discharge in stroke patients with nonvalvular atrial fibrillation and clarify the underlying characteristics potentially affecting that choice using the multicenter(More)