Hiroshi Kosaka

Jacques F.A.P. Miller2
Christian Kurts2
William R. Heath2
Francis R. Carbone2
2Jacques F.A.P. Miller
2Christian Kurts
2William R. Heath
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In this report, we show that cross-presentation of self-antigens can lead to the peripheral deletion of autoreactive CD8(+) T cells. We had previously shown that transfer of ovalbumin (OVA)-specific CD8(+) T cells (OT-I cells) into rat insulin promoter-membrane-bound form of OVA transgenic mice, which express the model autoantigen OVA in the proximal(More)
Recently, we demonstrated that major histocompatibility complex class I-restricted cross-presentation of exogenous self-antigens can induce peripheral T cell tolerance by deletion of autoreactive CD8+ T cells. In these studies, naive ovalbumin (OVA)-specific CD8+ T cells from the transgenic line OT-I were injected into transgenic mice expressing(More)
OBJECTIVES In order to clarify the effect of lead on higher cerebral functions, lead-exposed workers (Pb group) and controls were examined for event-related potentials. SUBJECTS AND METHODS Fourteen lead-exposed workers with a mean age of 57.1 yr (SD=4.27, range 48-64; lead concentration of whole blood ranged from 33 to 106 microg/dl with a mean of 58.6(More)
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