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It has been reported that widespread multisystem degeneration can occur in patients with sporadic amyotrophic lateral sclerosis (SALS) who have survived for long periods with artificial respiratory support (ARS). We report a case of SALS of 8 years and 8 months duration in a 71-year-old woman, who received ARS for 7 years and 8 months. In this patient, the(More)
SUMMARY The purpose of our study is to develop an algorithm that would enable the automated detection of lacunar infarct on T1-and T2-weighted magnetic resonance (MR) images. Automated identification of the lacunar infarct regions is not only useful in assisting radiologists to detect lacunar infarcts as a computer-aided detection (CAD) system but is also(More)
A probabilistic model was proposed in this research for fully-automated segmentation of liver region in non-contrast X-ray torso CT images. This probabilistic model was composed of two kinds of probability that show the location and density (CT number) of the liver in CT images. The probability of the liver on the spatial location was constructed from a(More)
LIM-kinase 1 (LIMK1) regulates actin cytoskeletal reorganization by phosphorylating and inactivating actin-depolymerizing factor and cofilin. We examined the role of LIMK1 in brain-derived neurotrophic factor (BDNF)-induced neuritogenesis in primary-cultured rat cortical neurons. Knockdown of LIMK1 or expression of a kinase-dead LIMK1 mutant suppressed(More)
  • Xuejun Zhang, Gobert Lee, Tetsuji Tajima, Teruhiko Kitagawa, Masayuki Kanematsu, Xiangrong Zhou +7 others
  • 2007
Segmentation of an abnormal liver region based on CT or MR images is a crucial step in surgical planning. However, precisely carrying out this step remains a challenge due to either connectivities of the liver to other organs or the shape, internal texture, and homogeneity of liver that maybe extensively affected in case of liver diseases. Here, we propose(More)
The incidence of liver diseases is very high in Asian countries. This paper introduces our computer-aided diagnosis (CAD) system for diagnosing liver cancer and describes the fundamental technologies employed in the system and its performance. The results showed that our system is useful for diagnosing liver cancer, and it is expected that employing CAD in(More)
Animal cells disassemble and reassemble their nuclear envelopes (NEs) upon each division. Nuclear envelope breakdown (NEBD) serves as a major regulatory mechanism by which mixing of cytoplasmic and nuclear compartments drives the complete reorganization of cellular architecture, committing the cell for division. Breakdown is initiated by(More)
Lamellipodium extension is crucial for cell migration and spreading. The rate of lamellipodium extension is determined by the balance between the rate of actin polymerization and the rate of actin retrograde flow. LIM kinase 1 (LIMK1) regulates actin dynamics by phosphorylating and inactivating cofilin, an actin-depolymerizing protein. We examined the role(More)
Computer aided diagnosis for pneumoconiosis using neural network is presented. The rounded opacities in the pneumoconiosis X-ray photo are picked up by a back propagation (BP) – neural network with several typical training patterns. The training patterns from 0.6 mm! to 30 mm! are made by simple circles. The neck problem for an automatic pneumoconiosis(More)