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  • Tatsuhiro Ishida, Masako Ichihara, +4 authors Hiroshi Kiwada
  • Chemistry, Medicine
  • Journal of controlled release : official journal…
  • 2006 (First Publication: 1 May 2006)
  • Steric stabilization of the surface of liposomes by a PEG conjugated lipid results in reduced recognition of the liposomes by the cells of the mononuclear phagocyte system and consequently extendedExpand
  • Xinyu Wang, Tatsuhiro Ishida, Hiroshi Kiwada
  • Chemistry, Medicine
  • Journal of controlled release : official journal…
  • 2007 (First Publication: 1 June 2007)
  • Earlier we reported that PEGylated liposomes lose their long-circulating characteristic when they are administrated twice in the same animal with certain intervals (referred to as the acceleratedExpand
  • Tatsuhiro Ishida, Masae Harada, Xin Yu Wang, Masako Ichihara, Kenji Irimura, Hiroshi Kiwada
  • Chemistry, Medicine
  • Journal of controlled release : official journal…
  • 2005 (First Publication: 1 July 2005)
  • We recently reported that a second dose of polyethylene glycol (PEG) (M.W. 2000)-modified liposomes (mPEG2000-liposomes) is rapidly cleared from the blood and accumulates in the liver when injectedExpand
  • Tatsuhiro Ishida, Masako Ichihara, Xinyu Wang, Hiroshi Kiwada
  • Chemistry, Medicine
  • Journal of controlled release : official journal…
  • 2006 (First Publication: 1 October 2006)
  • It is well known that steric stabilization of the surface of liposomes by a polyethyleneglycol (PEG) conjugated lipid results in reduced recognition of the liposomes by the cells of the mononuclearExpand
  • Tatsuhiro Ishida, Kazutaka Atobe, Xingyu Wang, Hiroshi Kiwada
  • Chemistry, Medicine
  • Journal of controlled release : official journal…
  • 2006 (First Publication: 1 October 2006)
  • The "accelerated blood clearance (ABC) phenomenon", causing PEGylated liposomes to be cleared very rapidly from the circulation upon repeated injection, has been reported to occur in rodents andExpand
  • Tatsuhiro Ishida, Xinyu Wang, Taro Shimizu, Kosuke Nawata, Hiroshi Kiwada
  • Chemistry, Medicine
  • Journal of controlled release : official journal…
  • 2007 (First Publication: 1 October 2007)
  • We recently reported that intravenous injections of "empty" PEGylated liposomes without encapsulated or surface coupled proteins elicit a PEG-specific IgM response in rats. In the present study,Expand
  • Tomotaka Kobayashi, Tatsuhiro Ishida, Yurie Okada, Saori Ise, Hideyoshi Harashima, Hiroshi Kiwada
  • Chemistry, Medicine
  • International journal of pharmaceutics
  • 2007 (First Publication: 1 February 2007)
  • The over-expression of P-glycoprotein (P-gp) has been associated with the development of multidrug resistance (MDR) in cancer cells. In this study, we examined whether transferrin receptor (Tf-R)Expand