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- Kazuichi Maruyama, Masaaki Ii, +9 authors J. Wayne Streilein
- The Journal of clinical investigation
- 2005
In the inflamed cornea, there is a parallel outgrowth of blood and lymphatic vessels into the normally avascular cornea. We tested whether adaptive and/or innate immune cells were actively involved… (More)
- Makiko Nakayama, Hiroshi Keino, +4 authors Akito Hirakata
- Retina
- 2012
PURPOSE
Optical coherence tomography (OCT) using enhanced depth imaging (EDI) allows evaluation of choroidal thickness. Our objective was to analyze subfoveal choroidal thickness by EDI-OCT before… (More)
- Sunao Sugita, Shintaro Horie, +8 authors Manabu Mochizuki
- Journal of immunology
- 2008
T cells that encounter ocular pigment epithelium in vitro are inhibited from undergoing TCR-triggered activation, and instead acquire the capacity to suppress the activation of bystander T cells.… (More)
- Hiroshi Keino, Masaru Takeuchi, +5 authors Masahiko Usui
- The British journal of ophthalmology
- 2007
AIMS
To investigate whether supplementation of natural CD4+CD25+ regulatory T cells ameliorates mouse experimental autoimmune uveoretinitis (EAU) induced by CD4+ T cell-dependent interphotoreceptor… (More)
- Hiroshi Keino, Hiroshi Goto, Masahiko Usui
- Graefe's Archive for Clinical and Experimental…
- 2002
Abstract Background. Sunset glow fundus is considered an important ocular finding for diagnosing and understanding the pathogenesis of Vogt-Koyanagi-Harada (VKH) disease. In this study, we… (More)
- Ayano Imai, Sunao Sugita, +5 authors Manabu Mochizuki
- Investigative ophthalmology & visual science
- 2012
PURPOSE
To determine whether supernatants of human retinal pigment epithelium (RPE) cells can convert CD4⁺ T cells into regulatory T cells (Tregs) under Treg-induction conditions in vitro and in… (More)
- Masaru Takeuchi, Hiroshi Keino, Takeshi Kezuka, Masahiko Usui, Osamu Taguchi
- Investigative ophthalmology & visual science
- 2004
PURPOSE
Prior work has shown that autoimmune uveoretinitis develops spontaneously in CD25(+)CD4(+) regulatory T-cell-depleted mice (Tr-depleted mice). In this study, the generation of autoantibodies… (More)
- Ichiro Naruse, Hiroshi Keino, Yoshihiko Kawarada
- Histochemistry
- 1994
Cyclophosphamide induced fragmented nuclei in mouse thymic epithelial cells. Agarose gel electrophoresis showed the fragmentation of the DNA extracted from mouse thymus exposed to cyclophosphamide.… (More)
- Hiroshi Keino, Annabelle Ayame Okada
- The British journal of ophthalmology
- 2007
B ehçet’s disease is a multisystem disorder named after the Turkish dermatologist, Hulusi Behçet (1889–1948), who recognised and reported in 1937 a triad of symptoms consisting of recurrent eye… (More)
- Yoshihiko Usui, Yoko Okunuki, +7 authors Masaru Takeuchi
- Experimental eye research
- 2008
The interaction of programmed death-1 (PD-1) expressed on T cells with its ligands B7H1 (PDL1) and B7DC (PDL2) is known to be a mechanism of T cell inhibition. In the present study, we examined… (More)