Hiroshi Kanai

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BACKGROUND Although a significant progress has been made in the management of ischemic heart disease (IHD), the number of severe IHD patients is increasing. Thus, it is crucial to develop new, non-invasive therapeutic strategies. In the present study, we aimed to develop low-intensity pulsed ultrasound (LIPUS) therapy for the treatment of IHD. METHODS AND(More)
This paper describes a new method of accurately estimating the parameters of an autoregressive (AR) process contaminated by high-level white noise. Based on the phase matching technique, it minimizes the difference between the phase of the all-zero model and the phase of the maximum phase signal reconstructed from the power spectrum of the observed signal.(More)
Artery-wall motion due to the pulsation of the heart is often measured to evaluate mechanical properties of the arterial wall. Such motion is thought to occur only in the arterial radial direction because the main source of the motion is an increase of blood pressure. However, it has recently been reported that the artery also moves in the longitudinal(More)
A prototype of wireless surface electrical stimulation system combined with the fuzzy FES controller was developed for rehabilitation training with functional electrical stimulation (FES). The developed FES system has three features for rehabilitation training: small-sized electrical stimulator for surface FES, wireless connection between controller and(More)
Cardiovascular diseases are risk factors for depression in humans. We recently proposed that σ1 receptor (σ1R) stimulation rescued cardiac hypertrophy and heart failure induced by transverse aortic constriction (TAC) in mice. Importantly, σ1R stimulation reportedly ameliorates depression-like behaviors in rodents. Thus, we hypothesized that impaired σ1R(More)
Anthracyclines are among the most effective and widely used anticancer drugs; however, their use is limited by serious cardiotoxicity. Early detection is necessary to prevent the high mortality rate associated with heart failure (HF). We evaluated cardiac function in 142 patients using conventional echocardiography and the phased tracking method (PTM),(More)