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BACKGROUND Knowledge of the physical properties of atherosclerotic plaque is essential when evaluating its vulnerability in a clinical setting. Such knowledge, however, is still difficult to obtain with the various approaches developed to date. METHODS AND RESULTS This article describes a noninvasive method for evaluating the regional elasticity (the(More)
Noninvasive measurement of mechanical properties, such as elasticity, of the arterial wall, is useful for diagnosis of atherosclerosis. The elasticity of the arterial wall can be estimated by combining measurement of displacement of the arterial wall with that of blood pressure. In general, the displacement of the arterial wall is estimated from the phase(More)
Using a heart ischemia/reperfusion model in rats, we recently demonstrated that 3-[2-[4-(3-chloro-2-methylphenyl)-1-piperazinyl]ethyl]-5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazole dihydrochloride 3.5 hydrate (DY-9760e), a calmodulin inhibitor, is a cardioprotective drug. Here, we examined cardioprotective mechanisms of DY-9760e in hypertrophy and heart(More)
This paper describes a new method of accurately estimating the parameters of an autoregressive (AR) process contaminated by high-level white noise. Based on the phase matching technique, it minimizes the difference between the phase of the all-zero model and the phase of the maximum phase signal reconstructed from the power spectrum of the observed signal.(More)
BACKGROUND Although a significant progress has been made in the management of ischemic heart disease (IHD), the number of severe IHD patients is increasing. Thus, it is crucial to develop new, non-invasive therapeutic strategies. In the present study, we aimed to develop low-intensity pulsed ultrasound (LIPUS) therapy for the treatment of IHD. METHODS AND(More)
BACKGROUND We previously reported the arterial elasticity value we measured to reflect the characteristic features of vessel walls, and to possibly be useful for detecting early stage atherosclerosis in type 2 diabetes. Obesity, especially visceral adiposity, is well known to play a crucial role in the development of metabolic disorders and atherosclerosis.(More)
A prototype of wireless surface electrical stimulation system combined with the fuzzy FES controller was developed for rehabilitation training with functional electrical stimulation (FES). The developed FES system has three features for rehabilitation training: small-sized electrical stimulator for surface FES, wireless connection between controller and(More)
Artery-wall motion due to the pulsation of the heart is often measured to evaluate mechanical properties of the arterial wall. Such motion is thought to occur only in the arterial radial direction because the main source of the motion is an increase of blood pressure. However, it has recently been reported that the artery also moves in the longitudinal(More)