Hiroshi Horimoto

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Allogeneic hepatocyte and fetal liver transplantation and xenogeneic hepatocyte transplantation were performed in Nagase's analbuminemic (NAR, RT1(1)) rats, and the functional and morphological changes of intrasplenic grafts under FK506 immunosuppression were examined. Normal male Wistar Shi rats (RT1k) and male BALB/C mice were used as donors. Serum(More)
We investigated the effects of monoclonal antibodies (mAbs) against lymphocyte function-associated antigen-1 (LFA-1) and intercellular adhesion molecule-1 (ICAM-1) on intrasplenic allogenic and xenogenic hepatocyte transplantation (HCTx) to analbuminemic rats. Ten to 12-wk-old male Nagase's analbuminemic rats (RT1l) were used as recipients, Wistar/Shi rats(More)
Selectins promote a rolling phenomenon of leukocytes along activated endothelial surfaces, which is the first step in the events that ultimately lead to leukocyte transmigration at acute inflammatory sites. Our previous study revealed that sulfatide, which is one of the selectin inhibitors, prolonged graft survival in rat cardiac allografts. In the present(More)
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