Roderick MacKinnon28
Samuel S. Spicer25
Katsumi Doi20
Lawrence G. Palmer20
Daisuke Yamauchi13
24Takeshi Kubo
11Adrian Münscher
10Hongliang Li
10Chizuru Tsuzuki
8Christoph Lossin

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Expression and clustered distribution of an inwardly rectifying potassium channel, KAB-2/Kir4.1, on mammalian retinal Müller cell membrane: their regulation by insulin and laminin signals.
Inwardly rectifying potassium (K+) channels (Kir) in Müller cells, the dominant glial cells in the retina, are supposed to be responsible for the spatial buffering action of K+ ions. The molecular… (More)
The endocochlear potential depends on two K+ diffusion potentials and an electrical barrier in the stria vascularis of the inner ear.
An endocochlear potential (EP) of +80 mV is essential for audition. Although the regulation of K(+) concentration ([K(+)]) in various compartments of the cochlear stria vascularis seems crucial for… (More)
An ATP-dependent inwardly rectifying potassium channel, KAB-2 (Kir4. 1), in cochlear stria vascularis of inner ear: its specific subcellular localization and correlation with the formation of…
Cochlear endolymph has a highly positive potential of approximately +80 mV. This so-called endocochlear potential (EP) is essential for hearing. Although pivotal roles of K+ channels in the formation… (More)
How is the highly positive endocochlear potential formed? The specific architecture of the stria vascularis and the roles of the ion-transport apparatus
Cochlear endolymph, an extracellular solution containing 150 mM K+, exhibits a positive potential of +80 mV. This is called the endocochlear potential (EP) and is essential for audition. The… (More)