Hiroshi Hatano

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Takashi Ariizumi1
Akira Ogose1
Takahiko Hayashi1
Tetsuro Yamagishi1
1Takashi Ariizumi
1Akira Ogose
1Takahiko Hayashi
1Tetsuro Yamagishi
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The receptor-activator of nuclear kappaB ligand (RANKL) signaling pathway plays an important role in the regulation of bone growth and mediates the formation and activation of osteoclasts. Osteoclasts are involved in significant bone resorption and destruction. Denosumab is a fully human monoclonal antibody against RANKL that specifically inhibits(More)
PURPOSE To describe a case of bilateral herpes simplex keratitis accompanying chronic graft-versus-host disease (GVHD). DESIGN Observational case report. CASE REPORT An 11-year-old boy with myelocytic leukemia underwent allogeneic bone marrow transplantation. He developed symptoms of the skin, eyes, and mouth, and lip biopsy indicated chronic GVHD.(More)
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