Hironobu Kohda

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Fischer rats became resistant to syngeneic hepatocellular carcinoma (FAA-HTC1) cells on repeated sensitization with mitomycin C-treated FAA-HTC1 cells. In contrast, FAA-HTC1 cells injected into the liver killed normal control Fischer rats within 2 months. Histopathological studies revealed massive accumulation of mononuclear cells in the tumor tissues of(More)
Interleukin 6 (IL-6) is produced by not only the lymphoid cells but also various non lymphoid cells (1). IL-6 is also known as multifunctional cytokine such as B-cell stimulatory factor 2, interferon beta 2, 26-kDa protein and hepatocyte stimulating factor. In this study, we investigated the effects of interleukin 1 (IL-1) and tumor necrosis factor (TNF) on(More)
To clarify the immunological effects of transcatheter arterial embolization (TAE) therapy for hepatocellular carcinoma (HCC), we investigated changes in the production of interleukin I (IL-I) alpha, as well as beta, determined by enzyme-linked immunosorbent assay (ELISA) before and after TAE therapy. Eleven patients with nonresectable HCC received(More)
Effects of several cytokines on des-gamma-carboxy prothrombin (PIVKA II) synthesis in human hepatoma cells were investigated to know the process of PIVKA II production during a liver allograft rejection. Human recombinant interleukin-6 (IL-6) significantly stimulated the PIVKA II synthesis without any influence on the cell proliferation. The effect was(More)
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