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Comparative study of the endocrine-disrupting activity of bisphenol A and 19 related compounds.
TLDR
The results suggest that the 4-hydroxyl group of the A- phenyl ring and the B-phenyl ring of BPA derivatives are required for these hormonal activities, and substituents at the 3,5-positions of the phenyl rings and the bridging alkyl moiety markedly influence the activities. Expand
Supplemental Silk Protein, Sericin, Suppresses Colon Tumorigenesis in 1,2-Dimethylhydrazine-Treated Mice by Reducing Oxidative Stress and Cell Proliferation
TLDR
It is suggested that dietary sericin suppresses the development of colon tumors by reducing oxidative stress, cell proliferation, and nitric oxide production. Expand
Identifying target genes regulated downstream of Cdx2 by microarray analysis.
TLDR
Differential expression of 23 genes involved in the Notch signaling pathway, xenobiotic metabolism, enzymes associated with tumor suppression, RNA binding protein, receptors, signal transduction, and transcription factors were confirmed by a semi-quantitative reverse transcription-polymerase chain reaction (RT-PCR) analysis using gene-specific primers. Expand
Silk protein, sericin, suppresses DMBA-TPA-induced mouse skin tumorigenesis by reducing oxidative stress, inflammatory responses and endogenous tumor promoter TNF-alpha.
TLDR
The results suggest that sericin possesses protective effect against tumor promotion in mouse skin by suppressing oxidative stress, inflammatory responses and TNF-alpha. Expand
Altered expression of a putative progenitor cell marker DCAMKL1 in the rat gastric mucosa in regeneration, metaplasia and dysplasia
TLDR
The ultrastructural appearance ofDCAMKL1-positive cells and the expression patterns of DCAMkL1 in normal and pathological states indicate that the cells belong to a progenitor cell population. Expand
The Role of Glucuronidation in 7‐Ethyl‐10‐hydroxycamptothecin Resistance in vitro
TLDR
Results imply that npregulation of UGT activity in PC‐7/CPT cells may contribute in part to SN‐38 resistance, and illustrate the importance of drug metabolism within malignant cells themselves, as a cause of drug resistance. Expand
Dietary vitamin B6 suppresses colon tumorigenesis, 8-hydroxyguanosine, 4-hydroxynonenal, and inducible nitric oxide synthase protein in azoxymethane-treated mice.
TLDR
The results suggest that the preventive effect of vitamin B6 against colon tumorigenesis is at least in part mediated by reducing oxidative stress and nitric oxide production. Expand
Successful treatment of cap polyposis by avoidance of intraluminal trauma: clues to pathogenesis
TLDR
This work describes two cases of cap polyposis with protein-losing enteropathy and describes two successful treatments that support a causal link ofpolyposis to prolapse. Expand
A Miso (Japanese Soybean Paste) Diet Conferred Greater Protection against Hypertension than a Sodium Chloride Diet in Dahl Salt-Sensitive Rats
TLDR
Results show that blood pressure was not increased by the miso diet, and Nephropathy was observed in both sexes of Dahl rats but not SD rats. Expand
Protective effects of a water-soluble extract from cultured medium of Ganoderma lucidum (Rei-shi) mycelia and Agaricus blazei murill against X-irradiation in B6C3F1 mice: Increased small intestinal
TLDR
It is suggested that MAK can act as a radioprotective agent against the shortening of survival time or the injury of crypt by X-irradiation. Expand
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