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- Yoichi Matsuo, Nubuo Ochi, +6 authors Sushovan Guha
- International journal of cancer
- 2009
CXC-chemokines are involved in the chemotaxis of neutrophils, lymphocytes and monocytes. However, role of these chemokines in tumorigenesis, especially with regard to interaction between tumor and… (More)
- Takaya Nagasaki, Mitsuhiro Hara, Hanayo Nakanishi, Hiroyuki Takahashi, Masahiko Sato, Hiromitsu Takeyama
- British Journal of Cancer
- 2014
Background:Interleukin-6 (IL-6) has an important role in cancer progression, and high levels of plasma IL-6 are correlated with a poor prognosis in a variety of cancers. It has also been reported… (More)
- Kazuyoshi Shiga, Masayasu Hara, +4 authors Huey-Jen Lin
- Cancers
- 2015
Cancer tissues are composed of cancer cells and the surrounding stromal cells (e.g., fibroblasts, vascular endothelial cells, and immune cells), in addition to the extracellular matrix. Most studies… (More)
- Tatsuya Tanaka, Hideyuki Ishiguro, +7 authors Hiromitsu Takeyama
- Journal of experimental & clinical cancer…
- 2010
BACKGROUND
The diagnosis of lymph node metastasis in esophageal cancer by the presence and number of metastatic lymph nodes is an extremely important prognostic factor. In addition, the indication of… (More)
- Jiachi Ma, Hirozumi Sawai, +6 authors Hiromitsu Takeyama
- Molecular and Cellular Biochemistry
- 2009
Phosphoinositide 3-kinase (PI3K) pathway exerts its effects through Akt, its downstream target molecule, and thereby regulates various cell functions including cell proliferation, cell… (More)
- Hiroki Takahashi, Hirozumi Sawai, +6 authors Tadao Manabe
- BMC gastroenterology
- 2006
BACKGROUND
Reactive lymphoid hyperplasia (RLH) of the liver is very rarely reported, and we encountered two cases of RLH of the liver in a patient with colon cancer.
CASE PRESENTATION
In the first… (More)
- Hirozumi Sawai, Yuji Okada, +4 authors Tadao Manabe
- Molecular Cancer
- 2005
Interaction with integrin and focal adhesion kinase (FAK) regulates the cancer cell adhesion and invasion into extracellular matrix (ECM). In addition, phosphorylation of FAK correlates with the… (More)
- Akira Yasuda, Hirozumi Sawai, +7 authors Tadao Manabe
- Molecular Cancer
- 2006
The transmembrane protein c-kit is a receptor tyrosine kinase (KIT) and KIT is expressed in solid tumors and hematological malignancies such as gastrointestinal stromal tumor (GIST), small-cell lung… (More)
- Hirozumi Sawai, Hitoshi Funahashi, +5 authors Tadao Manabe
- Oncology
- 2003
OBJECTIVE
To investigate the mechanisms of metastasis formation in metastatic human pancreatic cancer, we examined the enhancement in integrin expression, and adherence to and invasiveness into… (More)
- Hirozumi Sawai, Akira Yasuda, +7 authors Hiromitsu Takeyama
- BMC gastroenterology
- 2008
BACKGROUND
The tumour suppressor phosphatase and tensin homolog (PTEN) is an important negative regulator of cell-survival signaling. To evaluate the correlation between PTEN expression and… (More)