Hiromichi Aono

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The effect of variation in urinary flow rate (ml urine min-1, UF) on adjusted and non-adjusted urinary excretion of metals and organic substances was examined in ten 'healthy' men. The effect of UF was found to be eliminated when urinary concentrations of lead (Pb), hippuric acid (HA), delta-aminolevulinic acid (ALA) and coproporphyrin (CP) were adjusted to(More)
BACKGROUND Although vital statistics have indicated large Japanese-American differences in mortality rates for coronary heart disease (CHD), the magnitude of difference has not been documented well using comparable validation of cause of death. METHODS Population-based fatal CHD data were compared between the Oita Cardiac Death Survey, Japan and the(More)
To evaluate the reversibility of the effect of lead on psychological performance, five performance scale subtests of the Wechsler Adult Intelligence Scale were conducted twice at two-yr intervals on 17 gun-metal foundry workers who had initial blood lead (BPb) concentrations of 30-64 (median 40) micrograms/dl. The results indicated that psychological(More)
To evaluate the effects of calcium disodium ethylenediamine tetraacetate (CaEDTA) on the behavior of 8 heavy metals in human urine and blood, CaEDTA was administered for 1 h by intravenous injection to 18 male metal foundry workers, whose blood lead concentrations (PbB) were between 16 and 59 (mean 34) microg/dl. Significant increases were found in urinary(More)
In order to estimate the number of deaths from ischemic heart disease (IHD) in a Japanese city, we reevaluated heart disease deaths among residents aged 25-74 years by examining their clinical records. During the 2-year period from 1987 to 1988, 271 deaths among this population were attributed to heart disease. The recorded underlying cause of death was IHD(More)
To evaluate the effects of lead, zinc and copper in the causation of physiological changes in the central and peripheral nervous systems, we measured the latencies of pattern-reversal, visually-evoked potential (VEP) and of short-latency, somatosensory-evoked potential (SSEP) twice at a 12-month interval in nineteen gun metal founders exposed to lead, zinc(More)
To examine the antagonistic effects of lead, zinc and copper on the nervous system in man, we measured maximal motor and sensory conduction velocities (MCV and SCV, respectively) in the distal radial and median nerves in 20 gun metal founders with asymptomatically increased absorption of these metals [blood lead concentrations ranged from 16 to 64(More)
The effects of urinary volume on adjusted and nonadjusted urinary excretion of 11 heavy metals and organic substances were examined in relation to plasma and erythrocyte concentrations in 19 metal workers under conditions of water restriction and loading. Blood lead concentrations in these workers ranged from 25 to 59 micrograms/dl. The results indicated(More)
To estimate "filterable" plasma concentration (FPx), glomerular filtration, tubular balance, and renal clearance of heavy metals and organic substances, the authors examined the regressions of the 24-hr urinary excretion on glomerular filtration rate [GFR, 24-hr endogenous creatinine (Cn) clearance] in 19 gun-metal foundry workers with blood lead (Pb)(More)