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BACKGROUND Nicotine is responsible for smoking dependence and is mainly metabolised by CYP2A6. Several types of genetic polymorphism of CYP2A6 have been reported, but their relation to smoking habit and chronic obstructive pulmonary disease (COPD) phenotypes has not been fully clarified. METHODS 203 current or ex-smokers (lifelong cigarette consumption(More)
Case Study A 67-year-old man with untreated hypertension was admitted due to sudden onset involuntary movements involving the left arm and leg. Examination disclosed irregular coarse and twisting movement involving both distal and proximal muscles in the left arm and leg (Figure 1A). Magnetic resonance imaging and computed tomography of the brain revealed(More)
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