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Fingolimod phosphate (FTY720) is a sphingosine 1-phosphate (S1P) receptor agonist that is being used as a new oral drug for multiple sclerosis. FTY720 prevents lymphocytes from moving out of the lymphoid organs and inhibits autoreactive lymphocytes from infiltrating the central nervous system. Whether FTY720 directly affects microglia-the innate immune(More)
  • H Noda
  • 1986
It has been shown in the previous reports the immune system of mice is activated during liver regeneration following partial hepatectomy and lymph node cells activated in vivo suppress the syngeneic mixed hepatectomized liver cell-lymphocyte reaction (sMLHLR). In this report, it is demonstrated that the suppressor activity of lymphocytes in vivo by liver(More)
1,3-Di(4-sulfamoylphenyl)triazene was abundantly produced by incubation of sulfanilamide (SA) and NaNO2 in human gastric juice. This reaction also occurred in acetate buffer (pH approximately 4) at 37 degrees C as well as in hydrochloric acid (pH < 1) under ice cooling, with the product forming in almost the same amount. This phenomenon indicated the broad(More)
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