Hiromasa Nagata

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The inflammatory response triggered by transfusion is implicated in the pathophysiology of transfusion-related immunomodulation. The authors hypothesized that two distinctive autotransfusion methods, acute normovolemic hemodilution (ANH) and preoperative donation (PD), have different influences on both inflammatory mediator generation during storage and the(More)
BACKGROUND The purpose of this study was to determine the effects of transient arterial blood pressure change on the accuracy of the FloTrac™/Vigileo™ monitor (Edwards Lifesciences, Irvine, CA). METHODS We compared stroke volume determined with the FloTrac/Vigileo with Doppler during anesthetic induction in 20 patients undergoing abdominal aortic(More)
Atrial natriuretic peptide (ANP) has been known to be protective against hepatic ischemia/reperfusion injury. The purpose of this study was to verify the hypothesis that ANP conserves microvascular circulation and reduces ischemia–reperfusion injury in the in vivo rabbit model. With IRB approval, 30 male Japanese white rabbits under pentobarbital anesthesia(More)
RATIONALE Cell-free hemoglobin (CFH) is a potent oxidant associated with poor clinical outcomes in a variety of clinical settings. Recent studies suggest that acetaminophen (APAP), a specific hemoprotein reductant, can abrogate CFH-mediated oxidative injury and organ dysfunction. Preoperative plasma CFH levels are independently associated with primary graft(More)
INTRODUCTION In critically ill patients, excessive bed rest and immobilisation have been shown to cause disuse muscle atrophy, which contributes to prolonged hospitalisation and decreased activity of daily living (ADL) levels. However, the degree and site specificity of acute disuse muscle atrophy in critically ill patients during a relatively short(More)
Despite recent advances in medical care, mortality due to sepsis, defined as life-threatening organ dysfunction caused by a dysregulated host response to infection, remains high. Fluid resuscitation and vasopressors are the first-line treatment for sepsis in order to optimize hemodynamic instability caused by vasodilation and increased vascular(More)
This study investigated the accuracy of the NICO monitor equipped with the newer software. Additionally, the effects of the increased dead space produced by the NICO monitor on ventilatory settings were investi- gated. Forty-two patients undergoing elective aortic reconstruction participated in this prospective, obser- vational study at a university(More)
Background: The effect of volatile anesthetics on emergence agitation in adults remains unclear. We compared the degree of emergence agitation between desflurane and sevoflurane anesthesia in adults undergoing thyroid surgery. Findings: One hundred and sixteen patients with American Society of Anesthesiologists status 1 or 2 were randomized into two groups:(More)