Hiroko Natori

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Nilotinib is a second-generation BCR-ABL kinase inhibitor with improved potency and selectivity compared to imatinib. A Phase I/II dose-escalation study was designed to evaluate the efficacy, safety, and pharmacokinetics of nilotinib in Japanese patients with imatinib-resistant or -intolerant Philadelphia chromosome-positive (Ph+) chronic myelogenous(More)
We present a case of a submucosal tumor in the stomach that was suspicious for malignancy on preoperative endosonography. The resected tumor was histologically diagnosed as a ductal adenocarcinoma that originated in ectopic pancreatic tissue in the gastric wall. Although malignant transformation in ectopic pancreas is extremely rare, it remains an important(More)
Fecal bile acids (FBA) were analyzed by gas-liquid chromatography in 29 patients [17 with ulcerative colitis (UC) and 12 with adenomatosis coli (AC)] and 5 healthy volunteers. Seven UC and 9 AC patients had undergone total colectomy and J-shaped ileal pouch-anal anastomosis (JAA). The mean daily FBA output was similar for JAA and terminal ileostomy patients(More)
BACKGROUND In rectal cancer, preoperative evaluation of the depth of cancer invasion and the presence of pararectal lymph node metastasis is essential to determine appropriate operative procedures, especially in autonomic nerve preserving operations. For this evaluation, endoscopic ultrasonography (EUS) was performed prospectively in the following cases. (More)
Since 1978, J. Utsunomiya has performed total colectomy, mucosal proctectomy and ileoanal anastomosis (IAA) in 105 patients and analysed their results in 97 patients consisting of 61 of familial polyposis (FP) and 36 of ulcerative colitis (UC) those who have been observed for two months to 10 years after operation. The operative procedures were classified(More)
nents from fungi, several immunosuppressive 2-pyrones, multiforisins A—F and macrophin have been isolated from Ascomycetes, Gelasinospora multiforis CAILLEUX and Diplogelasinospora grovesii UDAGAWA et HORIE, respectively. Successively, it was found that the defatted AcOEt extracts of two Ascomycetes, Gelasinospora heterospora CAILLEUX, and G. longispora(More)
Liver injury following administration of some antibiotics of inhibitors of RNA synthesis, actinomycin D, aflatoxin B1 and eycIoheximide, an inhibitor of protein synthesis as well as RNA synthesis, was studied experimentally on adult rats. Effects on 39 rats were studied 10 to 60 minutes after intravenous administration of actinomycin D in doses of 250/tg/kg(More)