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  • W. Ross Tracey, William A. Magee, Hiroko Masamune, Joseph J. Oleynek, Roger J W Hill
  • Medicine
  • Cardiovascular research
  • 1998 (First Publication: 1 October 1998)
  • OBJECTIVE The aim of this study was to characterize the adenosine A3 receptor agonist, N6-(3-chlorobenzyl)-5'-N-methylcarboxamidoadenosine (CB-MECA), evaluate its ability to reduce myocardialExpand
  • Allen J. Duplantier, Michael S. Biggers, +11 authors John W. Watson
  • Chemistry, Medicine
  • Journal of medicinal chemistry
  • 1996
  • In addition to having desirable inhibitory effects on inflammation, anaphylaxis, and smooth muscle contraction, PDE-IV inhibitors also produce undesirable side effects including nausea and vomiting.Expand
  • Cornelia S Carr, Roger J W Hill, +4 authors Derek M Yellon
  • Medicine
  • Cardiovascular research
  • 1997 (First Publication: 1 October 1997)
  • OBJECTIVE Adenosine receptor activation has been implicated in the mechanism of ischaemic preconditioning protection. Evidence suggests adenosine A1 receptor involvement, and possibly A3 receptorExpand
  • Peter J. Rix, Andrew Vick, +10 authors Hiroko Masamune
  • Medicine
  • Clinical Pharmacokinetics
  • 2014 (First Publication: 25 November 2014)
  • IntroductionThe efficacy of nebulized sodium nitrite (AIR001) has been demonstrated in animal models of pulmonary arterial hypertension (PAH), but it was not known if inhaled nitrite would be wellExpand
  • Michael Paul Deninno, Hiroko Masamune, +10 authors Roger J W Hill
  • Chemistry, Medicine
  • Bioorganic & medicinal chemistry letters
  • 2006 (First Publication: 1 May 2006)
  • Using a combination of parallel and directed synthesis, the discovery of a highly potent and selective series of adenosine A3 agonists was achieved. High aqueous solubility, required for the intendedExpand
  • John B. Cheng, Kelvin J Cooper, +8 authors John P. Umland
  • Chemistry
  • 1995 (First Publication: 1 September 1995)
  • Abstract The synthesis and biological properties of a novel series of potent and selective phosphodiesterase type IV (PDE IV) inhibitors are described. These catechol benzimidazoles were designedExpand