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Orexin-A does not stimulate food intake in old rats.
Aging is associated with a progressive decrease in appetite and food intake. Both A and B orexins, expressed in specific neurons of the lateral hypothalamic area, have been implicated in theExpand
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Differences in the Appetite-Stimulating Effect of Orexin, Neuropeptide Y and Ghrelin among Young, Adult and Old Rats
Aging is associated with a progressive decrease in appetite and food intake. The appetite-stimulating peptides orexin A, neuropeptide Y (NPY) and ghrelin are known to play a critical role in foodExpand
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Development expression of the neural adhesion molecule F3 in the rat brain
We cloned a cDNA encoding rat F3 and analyzed the nucleotide sequences. The results have shown that rat F3 is comprised of 1021 amino acid residues. It shared 99% and 76% identities with mouse andExpand
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Pyruvate therapy for Leigh syndrome due to cytochrome c oxidase deficiency.
BACKGROUND Recently we proposed the therapeutic potential of pyruvate therapy for mitochondrial diseases. Leigh syndrome is a progressive neurodegenerative disorder ascribed to either mitochondrialExpand
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Age-related decline of F3/Contactin in rat hippocampus
F3/Contactin (F3), a neural adhesion molecule, is known to be involved in developmental and regenerative processes in the brain. We have investigated age-related change in the expression of F3 mRNAExpand
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Differences in ethanol ingestion between cholecystokinin-A receptor deficient and -B receptor deficient mice.
AIMS Cholecystokinin (CCK) modulates dopamine release in the nucleus accumbens through the CCK-A receptor (CCK-AR). The dopaminergic neurotransmission between the ventral tegmental area and theExpand
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Extensive screening system using suspension array technology to detect mitochondrial DNA point mutations.
We established an extensive and rapid system using suspension array to detect 61 representative mitochondrial DNA (mtDNA) heteroplasmic or homoplasmic point mutations (29 for Series A and 32 forExpand
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Extensive and rapid screening for major mitochondrial DNA point mutations in patients with hereditary hearing loss
Sensorineural hearing loss (HL) is one of the most frequent clinical features in patients with mitochondrial diseases caused by mitochondrial DNA (mtDNA) mutations, and hearing is impaired in overExpand
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Decreased hydrogen-potassium-activated ATPase (H+-K+-ATPase) expression and gastric acid secretory capacity in aged mice.
Gastric acid secretion in response to chemical stimulation and to mechanical stimulation was investigated in adult and old mice. The protein expression of a proton pump (H(+)-K(+)-ATPase), a markerExpand
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Gastric acid secretion in cholecystokinin-1 receptor, -2 receptor, and -1, -2 receptor gene knockout mice
Gastrin is important for stimulating acid secretion as well as differentiating gastric mucosal cells via cholecystokinin-2 receptors (CCK-2Rs). In turn, CCK acts preferably via CCK-1R to releaseExpand
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