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  • Hiroki Koshimichi, Kousei Ito, Akihiro Hisaka, Masashi Honma, Hiroshi Suzuki
  • Medicine, Chemistry
  • Drug metabolism and disposition: the biological…
  • 2011 (First Publication: 1 December 2011)
  • Medication use during lactation is a matter of concern due to unnecessary exposure of infants to drugs. Although some studies have predicted the extent of drug transfer into milk from physicochemicalContinue Reading
  • Hiroki Koshimichi, Toru Ishibashi, Nao Kawaguchi, Chisako Sato, Akira Kawasaki, Toshihiro Wajima
  • Medicine
  • Clinical Drug Investigation
  • 2018 (First Publication: 1 December 2018)
  • Background and ObjectiveBaloxavir marboxil, a prodrug that is metabolized to baloxavir acid, suppresses viral replication by inhibiting cap-dependent endonuclease. This first-in-human phase I studyContinue Reading
  • Hiroki Koshimichi, Yoshiyuki Tsuda, Toru Ishibashi, Toshihiro Wajima
  • Chemistry, Medicine
  • Journal of pharmaceutical sciences
  • 2019 (First Publication: 1 May 2019)
  • Baloxavir marboxil, a prodrug that is metabolized to baloxavir acid, suppresses viral replication by inhibiting cap-dependent endonuclease. Our aim is to characterize its pharmacokinetics andContinue Reading