Hirokazu Nagoshi

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p63/p51, a homolog of the tumor suppressor protein p53, is chiefly expressed in epithelial tissues, including the epidermis. p63 affects cell death similar to p53, and also plays important roles in the development of epithelial tissues and the maintenance of epithelial stem cells. Because it remains unclear how p63 regulates epithelial cell differentiation,(More)
The tumor suppressor gene p53 plays a central role in determining cell fate in response to DNA damage; cells may undergo either senescence or apoptosis, depending on cell type. Phosphorylation of Serine 46 (Ser(46)) of p53 is considered to be a primary determinant for the induction of apoptosis, by selectively inducing transactivation of p53 target genes(More)
OBJECTIVES p51/p63 gene, one of the p53 families, is specifically expressed in tooth germ epithelial cells and is essential for tooth development. This study aims to elucidate roles of p51/p63 in ameloblastic cell differentiation. MATERIALS AND METHODS We determined expression pattern of each of p51/p63 isoforms by reverse transcriptase-polymerase chain(More)
In the crystal structure of the title compound, C(6)H(4)N(2)·C(6)H(2)Cl(2)O(4), two chloranilic acid (systematic name: 2,5-dichloro-3,6-dihydr-oxy-1,4-benzoquinone) mol-ecules are connected by O-H⋯O hydrogen bonds to form a dimeric unit. The pyridine-4-carbonitrile mol-ecules are linked on both sides of the dimer via N⋯H⋯O hydrogen bonds to give a(More)
In the three isomeric salts, all C(6)H(7)N(2)O(+).C(6)HCl(2)O(4)(-), of chloranilic acid (2,5-dichloro-3,6-dihydroxy-1,4-benzoquinone) with 2-, 3- and 4-carbamoylpyridine, namely, 2-carbamoylpyridinium hydrogen chloranilate (systematic name: 2-carbamoylpyridinium 2,5-dichloro-4-hydroxy-3,6-dioxocyclohexa-1,4-dienolate), (I), 3-carbamoylpyridinium hydrogen(More)
In the crystal structure of the title salt, C(6)H(6)NO(2) (+)·C(6)HCl(2)O(4) (-), the pyridine ring and the mean plane of the hydrogen chloranilate anion form a dihedral angle of 77.40 (8)°. The ionic components are held together by N-H⋯O and O-H⋯O hydrogen bonds, forming a supra-molecular ladder. C-H⋯O inter-actions are also present.
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