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A more efficient method to generate integration-free human iPS cells
We report a simple method, using p53 suppression and nontransforming L-Myc, to generate human induced pluripotent stem cells (iPSCs) with episomal plasmid vectors. We generated human iPSCs from… Expand
Feasibility of HLA-haploidentical hematopoietic stem cell transplantation between noninherited maternal antigen (NIMA)-mismatched family members linked with long-term fetomaternal microchimerism.
Based on the hypothesis that long-term fetomaternal microchimerism is associated with acquired immunologic hyporesponsiveness to noninherited maternal antigens (NIMAs) or inherited paternal antigens… Expand
HLA mismatch combinations associated with decreased risk of relapse: implications for the molecular mechanism.
The finding that the risk of relapse in hematologic malignancy decreases after allogeneic hematopoietic stem cell transplantation (HSCT) has lead to the concept of a graft-versus-leukemia (GVL)… Expand
Fetal-maternal microchimerism: impact on hematopoietic stem cell transplantation.
- T. Ichinohe, T. Teshima, K. Matsuoka, E. Maruya, Hiroh Saji
- Medicine, Biology
- Current opinion in immunology
- 1 October 2005
Reciprocal cell traffic between mother and fetus during pregnancy gives rise to postpartum fetal-maternal lymphohematopoietic microchimerism, which is frequently detected in blood or tissue from… Expand
HLA-DRB1 and tumor necrosis factor gene polymorphisms in Japanese patients with multiple sclerosis
- J. J. Ma, M. Nishimura, Hideko Mine, Hiroh Saji, T. Uchiyama
- Medicine, Biology
- Journal of Neuroimmunology
- 1 December 1998
We studied genetic polymorphisms in the tumor necrosis factor (TNF) region as well as HLA-DRB1 of 42 patients with Western-type multiple sclerosis (MS) and 38 with Asian-type MS in Japan. The sex… Expand
Effects of HLA allele and killer immunoglobulin-like receptor ligand matching on clinical outcome in leukemia patients undergoing transplantation with T-cell-replete marrow from an unrelated donor.
- Y. Morishima, Toshio Yabe, +14 authors Y. Kodera
- Biology of blood and marrow transplantation…
- 1 March 2007
The responsible human leukocyte antigen (HLA) locus and the role of killer immunoglobulin-like receptor (KIR) ligand matching on transplantation outcome were simultaneously identified by multivariate… Expand
Understanding of HLA-conferred susceptibility to chronic hepatitis B infection requires HLA genotyping-based association analysis
Associations of variants located in the HLA class II region with chronic hepatitis B (CHB) infection have been identified in Asian populations. Here, HLA imputation method was applied to determine… Expand
Second Transplantation from HLA 2-Loci-Mismatched Mother for Graft Failure Due to Hemophagocytic Syndrome after Cord Blood Transplantation
- T. Tanaka, H. Matsubara, +11 authors T. Nakahata
- International journal of hematology
- 1 December 2004
A 7-year-old girl with acute myelogenous leukemia with multilineage dysplasia received unrelated cord blood transplantation but developed hemophagocytic syndrome (HPS) after sepsis with… Expand
Long-term Feto-Maternal Microchimerism: Nature’s Hidden Clue for Alternative Donor Hematopoietic Cell Transplantation?
During pregnancy, fetal hematopoietic cells carrying paternal human leukocyte antigens (HLA) migrate into maternal circulation, and, vice versa, maternal nucleated cells can be detected in fetal… Expand
Unmanipulated HLA-Haploidentical Bone Marrow Transplantation for the Treatment of Fatal, Nonmalignant Diseases in Children and Adolescents
Fetomaternal microchimerism has been demonstrated, and immunologic tolerance to unshared HLA antigens between mother and offspring may be suggested. We used T-cell-repleted bone marrow… Expand