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  • Alf Lamprecht, Nathalie Ubrich, +5 authors Claus Michael Lehr
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental…
  • 2001 (First Publication: 30 June 2002)
  • The use of nanoparticles for targeted oral drug delivery to the inflamed gut tissue in inflammatory bowel disease was examined. Such a strategy of local drug delivery would be a distinct improvementExpand
  • Hiroko Murakami, M. Kobayashi, Hirofumi Takeuchi, Yoshiaki Kawashima
  • Chemistry, Medicine
  • International journal of pharmaceutics
  • 1999 (First Publication: 1 October 1999)
  • PURPOSE The objectives of this study were to establish a new preparation method for poly(DL-lactide-co-glycolide) (PLGA) nanoparticles by modifying the spontaneous emulsification solvent diffusionExpand
  • Hirofumi Takeuchi, Jringjai Thongborisute, Yuji Matsui, Hikaru Sugihara, Hiromitsu Yamamoto, Yoshiaki Kawashima
  • Biology, Medicine
  • Advanced drug delivery reviews
  • 2005 (First Publication: 3 November 2005)
  • To design an effective particulate drug delivery system having mucoadhesive function, several mucoadhesion tests for polymers and the resultant particulate systems were developed. Mucin particleExpand
  • Yuji Kawashima, Hiromitsu Yamamoto, Hirofumi Takeuchi, Tomoaki Hino, Toshiyuki Niwa
  • Materials Science, Medicine, Chemistry
  • European journal of pharmaceutics and…
  • 1998 (First Publication: 30 June 1999)
  • Novel emulsion solvent diffusion methods in water or oil were developed to prepare the peptide (TRH and elcatonin)-loaded PLGA nanospheres, via the coprecipitation of drug and polymer in the emulsionExpand
  • Toshiyuki Niwa, Hirofumi Takeuchi, Tomoaki Hino, Noriyuki Kunou, Yoshiaki Kawashima
  • Chemistry, Materials Science
  • 1993 (First Publication: 1 May 1993)
  • Abstract Nanospheres with d , l -lactide/glycolide copolymer (PLGA) were prepared as a biodegradable polymeric carrier for both water-soluble and insoluble drugs by a novel spontaneous emulsificationExpand
  • Yuji Kawashima, Hiromitsu Yamamoto, Hirofumi Takeuchi, Yoshio Kuno
  • Chemistry, Medicine
  • Pharmaceutical development and technology
  • 2000 (First Publication: 1 January 2000)
  • The purpose of this work was to develop a novel mucoadhesive DL-lactide/glycolide copolymer (PLGA) nanosphere system to improve peptide absorption and prolong the physiological activity followingExpand
  • Yoshiaki Kawashima, Hirofumi Takeuchi, +4 authors Keiko Kawahara
  • Materials Science, Chemistry, Medicine
  • Pharmaceutical Research
  • 1993 (First Publication: 1 March 1993)
  • Tablets of acetaminophen as a model drug were prepared with low-substituted hydroxypropylcellulose (L-HPC) of various particle sizes at various loadings in the formulation. Drug release into anExpand