Hirofumi Akashi

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p53 is the most frequently mutated tumor suppressor gene in human neoplasia and encodes a transcriptional coactivator. Identification of p53 target genes is therefore key to understanding the role of p53 in tumorigenesis. To identify novel p53 target genes, we first used a comparative genomics approach to identify p53 binding sequences conserved in the(More)
BACKGROUND Gastric cancer is the third most common malignancy affecting the general population worldwide. Aberrant activation of KRAS is a key factor in the development of many types of tumor, however, oncogenic mutations of KRAS are infrequent in gastric cancer. We have developed a novel quantitative method of analysis of DNA copy number, termed digital(More)
This paper describes the Visible Human (VH) part of the Trans-Pacific Demonstrations of the G7 Information Society-Global Interoperability for Broadband Network (GIBN) Projects. Aiming at a worldwide Visible Human Anatomical Co-laboratory, an application (VHP Viewer) was developed, which was used for data transmission testing (Trans-Pacific Demonstration of(More)
Background: Gastric cancer is the third most common malignancy affecting the general population worldwide. Aberrant activation of KRAS is a key factor in the development of many types of tumor, however, oncogenic mutations of KRAS are infrequent in gastric cancer. We have developed a novel quantitative method of analysis of DNA copy number, termed digital(More)
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