Hiroe Ookura

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It is well known that the sodium thiosulfate (STS) decrease not only the nephrotoxicity which is a dose limiting factor of cisplatin (CDDP) chemotherapy but also its antitumor activity. Therefore, we examined the antitumor effect of CDDP in the human gastric cancer cell lines under various concentrations of STS. The cell lines used were KATO-III, MKN 28,(More)
BACKGROUND Although some studies conducted outside of Japan have addressed the effectiveness of intravenous immunoglobulins (IVIG) in treating infections, the dosing regimens and amounts used in Japan are very different from those reported. Here, we investigate the effectiveness of single-dose administration of IVIG in sepsis patients in Japan. METHODS We(More)
Echocardiography was performed in 18 patients with the aortitis syndrome and in 20 age-matched normal volunteers. The aortic root dimension, the aortic dimension at the level of the sinotubular ridge, the aortic arch dimension, the left ventricular internal dimension, the left atrial dimension, the interventricular septal thickness, and the left ventricular(More)
We evaluated the safety and stability of balloon infusors in which the distended elastomotor balloon acts as the energy source. Continuous intravenous administration of 5-fluorouracil with the infusor was carried out in nine patients with advanced gastrointestinal cancers. In additional two patients, morphine hydrochloride was administered continuously in(More)
Serum neuron-specific enolase (NSE) was measured in 48 newly diagnosed untreated patients with small cell lung cancer (SCLC) by radioimmunoassay. Serum NSE level elevated (greater than or equal to 15 ng/ml) in 50% of all patients. The positive ratio of NSE in patients with extensive disease (64%) was significantly higher than those in the patients with(More)
We, in the present study, studied the stability, operability, and economy as a whole of NT-proBNP assay, and further on the performance of diagnosing cardiac failure as a laboratory test. It was found to be superior to BNP assay not only as a reagent but also as a clinical test to diagnose cardiac functions. On the other hand, it is reported that NT-proBNP(More)
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