Hiroaki Makino

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A novel class of mitogen-activated protein kinase-activated protein kinase 2 (MAPKAP-K2) inhibitors was discovered through screening a kinase-focused library. A homology model of MAPKAP-K2 was generated and used to guide the initial SAR studies and to rationalize the observed selectivity over CDK2. An X-ray crystal structure of a compound from the active(More)
The authors examined periodic changes in endocrinological stress markers in saliva samples collected from 31 women who spent 8 days in a spa resort. Levels of salivary cortisol and chromogranin A (CgA) were evaluated by enzyme-linked immunosorbent assay. To evaluate health-related lifestyle factors, patterns of behavior, perceived stressors, and stress(More)
Using responses to questionnaires and results of saliva samples from 40 women, the authors assessed the effects on health of participation in a short leisure trip (2 nights, 3 d) to Kyushu Island in Japan. They addressed transportation, sightseeing, and group activities during the tour, which might differ from participants' usual activities. Levels of the(More)
Perilla leaf extract is known to have anti-inflammatory properties. Recently, we have demonstrated that rosmarinic acid, a polyphenolic liquid component in perilla, inhibits the allergic airway inflammation induced by house dust mites (HDMs) in vivo. The purpose of this study was to evaluate the effects of intratracheal (i.t.) exposure to volatile(More)
This paper presents a study on a control strategy for active vibration cancellation (AVC) and noise reduction in switched reluctance (SR) motors. It has been revealed that two-stage commutation control based on the natural frequency of the stator body has been effective in suppressing the vibration occurring on the stator body at the commutation. According(More)
The authors collected saliva samples from 15 married couples and 13 women staying with a female companion (N = 43) during an 8-day stay at a spa resort in Nagano, Japan. To examine changes in endocrinological stress markers, the authors evaluated participants' levels of salivary cortisol and chromogranin A (CgA) by enzyme-linked immunosorbent assay. By the(More)
Epidemiological and experimental studies have implicated that diesel exhaust particles are involved in increases in morbidity and mortality from lung diseases. Recently, we have demonstrated that rosmarinic acid, a polyphenolic liquid component in perilla, inhibits lung inflammation induced by diesel exhaust particles in vivo, partly through its(More)
1. Introduction Designing reliable systems has become more difficult in recent years. Besides conventional problems such as transistor leakage, the degradation and variation of transistor performance have a severe impact on the dependability of VLSI systems[1]-[3]. Negative-Bias-Temperature-Instability (NBTI) is one of the strongest reliability concerns for(More)
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