Hiroaki Maeda

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A severe lack of von Willebrand factor-cleaving protease (VWF-CP) activity can cause thrombotic thrombocytopenic purpura (TTP). This protease was recently identified as a member of the ADAMTS family, ADAMTS-13. It consists of a preproregion, a metalloprotease domain, a disintegrin-like domain, a thrombospondin type-1 motif (Tsp1), a cysteine-rich domain, a(More)
Tyrosine kinase-2 (Tyk2), a member of the Jak family of kinases, mediates the signals triggered by various cytokines, including type I IFNs, IL-12, and IL-23. In the current study, we investigated the in vivo involvement of Tyk2 in several IL-12/Th1- and IL-23/Th17-mediated models of experimental diseases, including methylated BSA injection-induced footpad(More)
Sheath blight, caused by Rhizoctonia solani, is one of the most serious diseases of rice. Among 33 rice accessions, mainly from National Institute of Agrobiological Sciences (NIAS) Core Collection, we found three landraces from the Himalayas-Jarjan, Nepal 555 and Nepal 8-with resistance to sheath blight in 3 years' field testing. Backcrossed inbred lines(More)
Internet traffic is continuously growing fast due to the rapid spread of the internet and the speed-up of the internet connection. Also, the applications provided on the internet have become more diversified. To support the QoS requirements for these internet applications, it would be better to measure the traffic volume according to the applications.(More)
Long Term Evolution (LTE) systems are attracting attention as next-generation mobile communication systems. Such systems have come to transfer and manage large volumes of data at high speed. Therefore, base stations have urgent requirements for devices that are friendlier to the environment, easier to install and cheaper to run. Further, there are needs to(More)
Tyrosine kinase-2 (Tyk2) participates in the signaling pathways of multiple cytokines in innate and acquired immunity. In the present study, we investigated the in vivo involvement of Tyk2 in anti-type II collagen antibody-induced arthritis (CAIA) using Tyk2-deficient mice. Hind paws of wild-type mice showed massive swelling and erythema by arthritogenic(More)
Rice (Oryza sativa L.) can produce black grains as well as white. In black rice, the pericarp of the grain accumulates anthocyanin, which has antioxidant activity and is beneficial to human health. We developed a black rice introgression line in the genetic background of Oryza sativa L. 'Koshihikari', which is a leading variety in Japan. We used Oryza(More)
A severe lack of von Willebrand factor– cleaving protease (VWF-CP) activity can cause thrombotic thrombocytopenic pur-pura (TTP). This protease was recently identified as a member of the ADAMTS family, ADAMTS-13. It consists of a pre-proregion, a metalloprotease domain, a disintegrin-like domain, a throm-bospondin type-1 motif (Tsp1), a cys-teine-rich(More)
PDE4B was previously shown to be a dominant PDE4 subtype of neutrophils. However, its physiological role in the neutrophil function has not been evaluated. In this study, the inhibitory effects of a phosphodiesterase 4B (PDE4B)- selective inhibitor (compound A) and subtype non-selective PDE4 inhibitors (roflumilast and cilomilast) were evaluated in human(More)