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The neural processes underlying shifts of visuospatial attention were studied in normal adults by non-invasive recording of brain electrical activity. Event-related evoked potentials (ERPs) were recorded during target detection tasks with targets preceded by central or peripheral directional cues in the visual field, which are hypothesized to provoke(More)
OBJECTIVE Non-target, deviant stimuli generate an earlier latency, front-central novelty P3, whereas correctly detected task-relevant stimuli generate a parietal maximal target P3. We examined whether the P3 component to novel stimuli is affected by dementing processes, and is therefore useful for distinguishing Alzheimer's type dementia (AD) from vascular(More)
The effects of age on the neural processes underlying shifts in visuospatial attention were studied by non-invasive recording of brain electrical activity. Event-related evoked potentials (ERPs) were recorded in young (age 28-36 years old) and elderly (59-74 years old) subjects during a target detection task. Targets were preceded by central or peripheral(More)
We investigated neurophysiologic correlates of shifting visual attention across the visual field. Event-related potentials (ERPs) were recorded in 12 normal subjects during a visual discrimination task in which target stimuli were presented at a predictable or unpredictable location in the eccentric visual field. Subjects were obliged to shift their(More)
The cerebellum has been implicated in higher cognitive functions including learning, memory, and attention as well as its well-known role in motor programming. Recent studies have suggested that the cerebellum plays a role in shifts of attention. We investigated the contribution of the cerebellum to visuospatial attentional ability in a trial-by-trial(More)
Recent evidence suggests that the frontal lobe plays an important role in an orienting response to novel events, and that frontal lobe dysfunction is linked to attentional and cognitive deficits in Parkinson's disease (PD). We tested the hypothesis that the neural network involved in novelty detection may be impaired in PD patients by studying event-related(More)
Transient global amnesia (TGA) is a syndrome of selective loss of recent memory without other neurological deficits. Auditory and visual P300s were recorded during and after TGA to investigate the contribution of the short-term memory system to P300 generation. The auditory P300 during TGA was comparable to that recorded 1 week and 9 months after TGA. In(More)
To investigate influence of social activity on normal brain aging, we studied the social activity score, cognitive functions, self-rating depression scale, cerebral blood flow (CBF), MRI and motor function in the normal elderly people living in different social environments. There was no difference in risk factors for stroke, MRI findings and CBF between(More)
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