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Host Prostaglandin E2-EP3 Signaling Regulates Tumor-Associated Angiogenesis and Tumor Growth

• Hideki Amano, Izumi Hayashi, +11 authors Masataka C Majima
• The Journal of experimental medicine
• 2003

Nonsteroidal antiinflammatories are known to suppress incidence and progression of malignancies including colorectal cancers. However, the precise mechanism of this action remains unknown. Using… (More)

Adiponectin stimulates prostaglandin E(2) production in rheumatoid arthritis synovial fibroblasts.

• Natsuko Kusunoki, Kanako Kitahara, +5 authors Shinichi Kawai
• Arthritis and rheumatism
• 2010

OBJECTIVE Adipokines may influence inflammatory and/or immune responses. This study was undertaken to examine whether adiponectin affects the production of prostaglandin E(2) (PGE(2)) by rheumatoid… (More)

Predictors of survival and causes of death in Japanese patients with systemic sclerosis.

• Atsushi Hashimoto, Satoko Tejima, +6 authors Shunsei Hirohata
• The Journal of rheumatology
• 2011

OBJECTIVE To clarify the mortality rates, causes of death, and contributing clinical factors in Japanese patients with systemic sclerosis (SSc). METHODS A cohort of 405 patients with SSc, who… (More)

Clinical usefulness of anti-RNA polymerase III antibody measurement by enzyme-linked immunosorbent assay.

• Takashi Satoh, Osamu Ishikawa, +13 authors Masataka Kuwana
• Rheumatology
• 2009

OBJECTIVE To evaluate the clinical usefulness of measuring anti-RNA polymerase (RNAP) III antibody with a commercially available ELISA in Japanese patients with SSc. METHODS This multicentre study… (More)

Incidence and the risk factor of malignancy in Japanese patients with systemic sclerosis.

• Atsushi Hashimoto, Yoshiyuki Arinuma, +5 authors Shunsei Hirohata
• Internal medicine
• 2012

OBJECTIVE To evaluate the incidence and risk factors for malignancy in Japanese patients with systemic sclerosis (SSc). METHODS A cohort of 405 Japanese patients with SSc who visited Kitasato… (More)

Host stromal bradykinin B2 receptor signaling facilitates tumor-associated angiogenesis and tumor growth.

• Yasuhiro Ikeda, Izumi Hayashi, +7 authors Masataka C Majima
• Cancer research
• 2004

We evaluated the significance of the host kallikrein-kinin system in tumor angiogenesis and tumor growth using two rodent models genetically deficient in a kallikrein-kinin system. Inoculation of… (More)

Down-regulation of lipoxin A4 receptor by thromboxane A2 signaling in RAW246.7 cells in vitro and bleomycin-induced lung fibrosis in vivo.

• Yoshinori Sato, Hidero Kitasato, +5 authors Izumi Hayashi
• Biomedicine & pharmacotherapy = Biomedecine…
• 2004

Lipoxins (LXs) are members of eicosanoid family that can be endogenously produced during cell-to-cell interactions such as platelet-leukocyte interactions. Anti-inflammatory function of lipoxin A4… (More)

Binary regulation of interleukin (IL)-6 production by EP1 and EP2/EP4 subtypes of PGE2 receptors in IL-1beta-stimulated human gingival fibroblasts.

• Kazuyuki Noguchi, Miki Shitashige, Hirahito Endo, Hirobumi Kondo, Isao Ishikawa
• Journal of periodontal research
• 2002

Prostaglandin E2 (PGE2) exerts its biological actions via EP receptors, which are divided into four subtypes of EP1, EP2, EP3 and EP4. In the present study, we investigated whether PGE2 regulated… (More)

Differential expression of leukotriene B4 receptor subtypes (BLT1 and BLT2) in human synovial tissues and synovial fluid leukocytes of patients with rheumatoid arthritis.

• Atsushi Hashimoto, Hirahito Endo, +9 authors Hirobumi Kondo
• The Journal of rheumatology
• 2003

OBJECTIVE To evaluate the role of leukotriene B4 (LTB4) receptors in inflammatory arthritis, we investigated the expression of BLT1 and BLT2 mRNA in synovial tissues of patients with rheumatoid… (More)

Recurrent paralytic ileus associated with strongyloidiasis in a patient with systemic lupus erythematosus.

• Hide Yoshida, Hirahito Endo, Sumiaki Tanaka, Akira Ishikawa, Hirobumi Kondo, Takeshi Nakamura
• Modern rheumatology
• 2006

We present an interesting case of recurrent paralytic ileus due to strongyloidiasis in a woman who was being treated with corticosteroids and immunosuppressants for systemic lupus erythematosus… (More)

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