Hina Shamshad

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In this paper, we have presented the demonstration of gold nanoparticles (Au NPs) functionalized with an anticancer drug, doxorubicin. Doxorubicin was assembled on gold via amino group. The reaction proceeded under mild acidic conditions. Au NPs could not be adsorbed on doxorubicin in alkaline solution because amino group was not protonated. However, under(More)
Simple, rapid and sensitive spectrophotometric procedures are developed for the analysis of gabapentin in pure form as well as in their pharmaceutical formulations. The methods are based on the reaction of gabapentin as n-electron donor with ninhydrin and pi-acceptors namely, 2,3,5,6-tetrachloro-1,4-benzoquinone, chloranilic acid,(More)
Controlling blood sugar levels is crucial for diabetic patients and is managed through administration of drugs such as gliquidone. Coadministration of antidiabetic drugs with H1-receptor antagonists is common but is also a source of concern due to potential coadministered drug interaction, especially in patients prone to allergic disorders. In this work, we(More)
Cetirizine, a second-generation H1 receptor antagonist, is used for the treatment of allergic disorders. For some of these diseases, combined H1 and H2 therapy generally is more effective than treatment exclusively with H1 or H2, although this synergistic effect has not been found in all studies. Moreover, extensive in vivo studies have investigated the(More)
A novel RP-HPLC method for the determination of mefenamic acid in raw material, different pharmaceutical forms, and in human serum for routine analysis, therapeutic purposes, and stability studies was developed and validated. This study is also a collection of studies performed on the physical and chemical aspects of mefenamic acid. The method developed(More)
A series of phosphonated carbocyclic 2'-oxa-3'-aza-nucleosides were synthesized via 1,3 dipolar cycloaddition and evaluated for their in vitro antiproliferative activity against the growth of cancer cell lines (MCF-7, A2780, HCT116) and normal non-transformed fibroblast (MRC5) using MTT assay. Synthesized compounds exhibited antiproliferative activity in(More)
BACKGROUND Tremendous research from last twenty years has been pursued to cure human life against HIV virus. A large number of HIV protease inhibitors are in clinical trials but still it is an interesting target for researchers due to the viral ability to get mutated. Mutated viral strains led the drug ineffective but still used to increase the life span of(More)
Towards the design of new class of podophyllotoxin to target topoisomerase II and tubulin as substantial target in cancer therapy, a series of isoxazolidine podophyllotoxin derivatives were designed. Topoisomerase in complex with etoposide and four β-tubulin in complex with zampanolide, taxol, vinblastine or colchicine were used as targets using GOLD5.2.2(More)
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