Examination of thin sections from the cerebral cortex of scrapie-infected hamster brains revealed characteristic circular 26-30 nm diameter tubulofilamentous particles, identical to those previously described in both experimentally induced scrapie in mice, hamsters and natural scrapie of sheep, bovine spongiform encephalopathy and human Creutzfeldt-Jakob… (More)
The abnormal aggregates of fibrillar material found in neurons in Alzheimer's disease, senile dementia, the Guam Parkinsonism-Dementia complex, Down's syndrome, and postencephalitic Parkinsonism were studied by means of tilt-stage electron microscopy and with X-ray images of scale models of a bifilar helix. The model fulfills the structural criteria… (More)
The perception of toxicity to nitric oxide (NO) and irradiation (IR) by three different cell types has been studied. The three cell types are the macrophage like RAW264.7 cells, EL4 lymphoma cells, and splenocytes, which represent the different components of a tumor. These three cell types respond differently to NO donors (SNP and SNAP) and radiation… (More)
A search procedure at the ultrastructural level revealed characteristic particulate structures in mice of two further laboratory stocks experimentally inoculated with scrapie. The structures represent a specific change related to scrapie disease; their relationship to the scrapie agent is discussed.
Ionizing radiation (IR) treatment results in activation of several DNA damage response molecules, such as ataxia telangiectasia, mutated (ATM), and DNA-dependent protein kinase (DNAPK) in mammals that are increasingly recognized for their potential roles in the sensing of DNA damage and initiating the subsequent protein kinase cascade. In vitro evidence… (More)
Morphology of intracytoplasmic nucleocapsid measles virus from mouse brain and tissue culture was studied with the use of ruthenium red by tilting and high resolution electron microscopy and compared with the paramyxovirus-like tubules found in multiple sclerosis (MS). Both in vivo and in vitro the measles nucleo-protein profiles were surrounded by 'fuzzy'… (More)
Herpes simplex virus (HSV) type I was injected into the right eye of 18-day-old New Zealand albino rabbits and the animals were killed on the fourth and eighth days after inoculation. Longitudinal section of the optic nerves and chiasma showed that both myelinated axons and neuroglial cells crossed at the chiasma. Semi-serial (1 micrometer) and ultrathin… (More)
The sequence of events which follows the intravitreal injection of herpes simplex virus (HSV) into one eye has been observed as it affects the eyes, optic nerves, and optic chiasm. Initially the injected (right) eye showed an intense iridocyclitis and about 16 days after inoculation an exudative retinal detachment was observed. A similar sequence of events… (More)