Hillary Selle Gramlich

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The decision whether a rotator cuff tear has a traumatic or degenerative origin still causes some controversy. Especially in medical expert appraisals the etiology of the rotator cuff tear plays an important role referring to insurance services for the patient. The purpose of this paper is to compare the intraoperative pathomorphologic shape of the cuff(More)
In einer prospektiven Studie wurden 48 Patienten mit einer eindeutigen traumatischen vorderen Schultererstluxation arthroskopiert und hinsichtlich der intraartikulären pathomorphologischen Veränderungen beurteilt. Die intraartikulären Schäden wurden qualifiziert und entsprechend dem Alter zugeordnet. Die Unterteilung der Patienten erfolgte in 3 Gruppen:(More)
Die medizinische Begutachtung der Rotatorenmanschettenruptur wird kontrovers diskutiert. Der Gutachter wird vor das Problem gestellt, ob die Ätiologie der Ruptur traumatischen oder letztendlich degenerativen Ursprungs ist. Auf diesem Hintergrund basierend wurde in einer prospektiven Studie bei insgesamt 56 Patienten mit operativ versorgter(More)
Activation-induced deaminase (AID) initiates diversity of immunoglobulin genes through deamination of cytosine to uracil. Two opposing models have been proposed for the deamination of DNA or RNA by AID. Although most data support DNA deamination, there is no physical evidence of uracil residues in immunoglobulin genes. Here we demonstrate their presence by(More)
The molecular features that allow activation-induced cytidine deaminase (AID) to target Ig and certain non-Ig genes are not understood, although transcription has been implicated as one important parameter. We explored this issue by testing the mutability of a non-Ig transcription cassette in Ig and non-Ig loci of the chicken B cell line DT40. The cassette(More)
Upon activation, B cells divide, form a germinal center, and express the activation induced deaminase (AID), an enzyme that triggers somatic hypermutation of the variable regions of immunoglobulin (Ig) loci. Recent evidence indicates that at least 25% of expressed genes in germinal center B cells are mutated or deaminated by AID. One of the most deaminated(More)
The purpose of this paper is to outline the treatment protocol for the first time traumatic anterior shoulder dislocator, with options including conservative, arthroscopic and open surgical treatment. Regarding the subclassification of the first time traumatic anterior dislocater, it is imparitive to differentiate between the unidirectional dislocator with(More)
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