Learn More
  • H McNulty
  • 1997
The earliest account of human folate requirement relates to its critical role in women's health. In 1872 Biemer described a severe, rapidly progressive and sometimes fatal anaemia of pregnancy (Rodriguez, 1978). However, the possibility that this might be related to a dietary deficiency was not considered until much later, when Wills (1931) established that(More)
Human insulin was glycated under hyperglycemic reducing conditions and a novel diglycated form (M(r) 6135.1 Da) was purified by RP-HPLC. Endoproteinase Glu-C digestion combined with mass spectrometry and automated Edman degradation localized glycation to Gly(1) and Phe(1) of the insulin A- and B-chains, respectively. Intraperitoneal (i.p.) administration of(More)
  • 1