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Creating a Structurally Realistic Finite Element Geometric Model of a Cardiomyocyte to Study the Role of Cellular Architecture in Cardiomyocyte Systems Biology.
With the advent of three-dimensional (3D) imaging technologies such as electron tomography, serial-block-face scanning electron microscopy and confocal microscopy, the scientific community hasExpand
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Mathematical models of calcium signalling in the context of cardiac hypertrophy
Throughout the average human lifespan, our hearts beat over 2 billion times. With each beat, calcium floods the cytoplasm of every heart cell, causing it to contract until calcium re-uptake allowsExpand
How does interaction between RyR and IP3R mediated calcium release shape the calcium transient for hypertrophic signalling in cardiomyocytes
Calcium plays a central role in mediating both contractile function and hypertrophic signalling in cardiomyocytes. While L-type Ca2+ channels (LCCs) trigger beat-to-beat release of calcium throughExpand
IP3R Ca2+ release shapes the cytosolic Ca2+ transient for hypertrophic signalling in cardiomyocytes.
Calcium plays a central role in mediating both contractile function and hypertrophicsignalling in cardiomyocytes. While L-type Ca2+ channels (LCCs) trigger beat-to-beat re-lease of calcium throughExpand
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Ca2+ Release via IP3 Receptors Shapes the Cardiac Ca2+ Transient for Hypertrophic Signaling.
Calcium (Ca2+) plays a central role in mediating both contractile function and hypertrophic signaling in ventricular cardiomyocytes. L-type Ca2+ channels trigger release of Ca2+ from ryanodineExpand
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Ca2+ release via IP3 receptors shapes the cytosolic Ca2+ transient for hypertrophic signalling in ventricular cardiomyocytes
Abstract Calcium (Ca2+) plays a central role in mediating both contractile function and hypertrophic signalling in ventricular cardiomyocytes. L-type Ca2+ channels trigger release of Ca2+ fromExpand
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Ca2+ release via IP3Rs increases RyR mediated Ca2+ spark frequency in ventricular cardiomyocytes without altering spark amplitude and duration
Calcium plays critical roles in cardiac cells, coupling electrical excitation to mechanical contraction with each heartbeat, while simultaneously mediating biochemical signals that regulate cellExpand