The marine natural product microsclerodermin A is a novel inhibitor of the nuclear factor kappa B and induces apoptosis in pancreatic cancer cells
- E. Guzmán, K. Maers, Jill C. Roberts, Hilaire V. Kemami-Wangun, D. Harmody, A. Wright
- BiologyInvestigational new drugs
- 1 February 2015
Treatment of AsPC-1 cells with microsclerodermin A resulted in an increase in IL-8 production without apparent induction of angiogenic factors and there is the possibility that inhibition of NFκB by micro sclerodermine A is mediated by the glycogen synthase kinase 3β pathway.