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Cremastrine, a pyrrolizidine alkaloid from Cremastra appendiculata.
A new pyrrolizidine alkaloid, cremastrine (1), was isolated from the bulbs of Cremastra appendiculata. Its configuration was determined by spectroscopic and chemical analyses. Compound 1 inhibitedExpand
  • 29
Nocardimicins A, B, C, D, E, and F, siderophores with muscarinic M3 receptor inhibiting activity from Nocardia sp. TP-A0674.
In the screening for muscarinic M3 receptor binding inhibitors from microbial secondary metabolites, the extract of Nocardia sp. TP-A0674 was found to be highly active. Bioassay-guided fractionationExpand
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Synthesis and pharmacological evaluation of 3-amino-1-(5-indanyloxy)-2-propanol derivatives as potent sodium channel blockers for the treatment of stroke.
In investigating potent sodium (Na(+)) channel blockers for the treatment of ischemic stroke, we synthesized a novel series of 3-amino-1-(5-indanyloxy)-2-propanol derivatives and evaluated theirExpand
  • 6
Synthesis of tricyclic compounds as steroid 5alpha-reductase inhibitors.
A series of 4-phenoxybutyric acid derivatives attached to a tricyclic skeleton were prepared and evaluated as 5alpha-reductase inhibitors. Structure activity relationships for these compounds inExpand
  • 1
Conformational studies on peptides having dipropylglycine (Dpg) or 1‐aminocycloheptanecarboxylic acid (Ac7c) within the sequence of l‐leucine (Leu) residues
A conformational analysis of peptides having dipropylglycine (Dpg) or 1‐aminocycloheptanecarboxylic acid (Ac7c) within l‐leucine (Leu) residues was conducted in solution and in a crystal state. DpgExpand
  • 2
Synthesis and Pharmacological Evaluation of 3‐Amino‐1‐(5‐indanyloxy)‐2‐propanol Derivatives as Potent Dodium Channel Blockers for the Treatment of Stroke.
The 3-amino-1-(5-indanyloxy)-2-propanol derivative bearing a benzimidazole moiety (I) shows potent neuroprotective activity in a rat transient middle cerebral artery occlusion model and high bindingExpand
Refrigerateur-congelateur, controleur pour refrigerateur-congelateur, et procede de determination de fuite de refrigerant
Cette invention se rapporte a un refrigerateur-congelateur qui est capable de detecter de facon fiable la fuite de refrigerant du cycle de refrigeration, lequel utilise un compresseur, unExpand