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Identification of urinary miRNA biomarkers for detecting cisplatin-induced proximal tubular injury in rats.

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ASP2397 Is a Novel Natural Compound That Exhibits Rapid and Potent Fungicidal Activity against Aspergillus Species through a Specific Transporter

Under conditions of delayed treatment initiation in an IPA mouse model, ASP2397 had efficacy superior to that of posaconazole, with 100% survival and over 1 log10 CFU/g reduction in lung fungal burden.
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Ipragliflozin, an SGLT2 inhibitor, exhibits a prophylactic effect on hepatic steatosis and fibrosis induced by choline-deficient l-amino acid-defined diet in rats.

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Original Research: Potential of urinary nephrin as a biomarker reflecting podocyte dysfunction in various kidney disease models

Urinary nephrin-to-creatinine ratio level is suggested to be a useful and reliable biomarker for predicting the amelioration of podocyte dysfunction by candidate drugs in various kidney disease models with podocytes dysfunction.
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Antiproteinuric effect of pirfenidone in a rat model of anti-glomerular basement membrane glomerulonephritis.

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Developing Stage-dependent Retinal Toxicity Induced by l-glutamate in Neonatal Rats

The findings indicate the morphological consequences of glutamate-induced retinal excitotoxicity and glutamate target cells on each postnatal day and reveal that glutamate- induced retinal damage depends on developing stage.
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Gene expression profile in retinal excitotoxicity induced by L-glutamate in neonatal rats

Investigation of the time-course gene expression profile in the developing retina in neonatal rats revealed that Gadd45b and Ccl3 are considered to participate in retinal thinning induced by L-glutamate, and that the association of initial histopathological changes with the gene expression Profile in the retina inducedby L- glutamate was revealed.
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Identification and verification of novel biomarkers for drug-induced renal papillary necrosis in rats using toxicoproteomic and toxicogenomic approaches

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Urinary proteome profile of renal papillary necrosis in experimental model rats

This research presents a novel and scalable approach called “SmartPharmacy,” which automates the very labor-intensive and therefore time-heavy and expensive and therefore expensive and expensive process of drug discovery and development.
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Accumulation of brown pigment-laden macrophages associated with vascular lesions in the lungs of cynomolgus monkeys(Macaca fascicularis)

Findings suggested that partial fragmentation of the vascular elastic lamina followed by degeneration and necrosis of the tunica media caused blood leakage leading to the accumulation of hemosiderin-laden macrophages in the perivascular interstitium of the lungs.
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