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Oncogenic BRAF alleles are both necessary and sufficient for cellular transformation, suggesting that chemical inhibition of the activated mutant protein kinase may reverse the tumor phenotype. Here, we report the characterization of SB-590885, a novel triarylimidazole that selectively inhibits Raf kinases with more potency towards B-Raf than c-Raf.(More)
This work proposes a new coding scheme for the discrete memoryless two-user interference channel whose receivers can cooperate to decode their desired messages. The coding scheme is built upon Han-Kobayashi rate splitting and superposition coding at the transmitters, noisy network coding, and non-unique joint decoding at the receivers. As a case study the(More)
This paper presents an achievable rate region for a 2-user Gaussian Z-interference channel with a noiseless and bidirectional digital communication link between the receivers. The region is achieved by utilizing the rate-splitting encoding technique, and the decode-and-forward and compress-and-forward strategies. In the very strong interference regime, the(More)
We derive achievable rate regions for a 2-user Gaussian Z-interference channel with conferencing decoders. We identify different cases where the rate-limitedness of the conference link from the interference-free receiver to the interfered receiver affects the conferencing strategy as well as the achievable rate region. Furthermore, an outer bound to the(More)
We present a new achievable rate region for the discrete memoryless Z channel (DM-ZC) using Marton coding with rate splitting. The region is shown to include previously known achievable rate regions. Secondly we study a class of degraded Z channels, the bijective degraded Z channel (BDZC). An outer bound for the BDZC is proved, which is shown to meet the(More)
This paper proposes a new coding scheme for the discrete memoryless interference channel with a dedicated relay. The scheme is built upon rate-splitting encoding, layered noisy network coding, and joint decoding. The result is extended to two Gaussian channels. For the Gaussian channel whose relay is connected to the destinations via orthogonal links we(More)
This paper studies and derives new results for the interference channel with a relay (ICR). Three inner bounds for the discrete memoryless ICR are proposed, based on three coding strategies that employ layered code at the relay. The first scheme is inspired by layered noisy network coding, proposed by Lim et al. for the two-way relay channel, the second and(More)
This paper considers a discrete memoryless four-node network where two nodes want to send three independent messages to the other two nodes. The two receiving nodes are allowed to cooperate by means of a unidirectional noiseless link with finite capacity. A coding scheme is proposed which combines rate splitting, block Markov multi-level superposition(More)