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CD137 is a member of the TNFR-family with costimulatory function. Here we show that it also has many favorable characteristics as a surrogate marker for antigen-specific activation of human CD8(+) T cells. Although undetectable on unstimulated CD8(+) T cells, it is uniformly up-regulated 24 hours after stimulation on virtually all responding cells(More)
Innovations in gene discovery and the analysis of gene expression are facilitating the identification of a growing number of antigens that could potentially be targeted for immunotherapy of tumors. Methods to reliably generate antigen-specific T-cell responses in vitro would be useful not only to screen candidate antigens for immunogenicity prior to(More)
In this paper, we investigate the impact of the transmit spatial correlation on the performance of the spatial multiplexing Multiple-Input Multiple-Output (MIMO) Multi-User (MU) Ultra-WideBand (UWB) system in which a pre-equalizer and a Time Reversal (TR) pre-filter are deployed at the transmitter. The combination of the pre-equalizer and the pre-filter is(More)
Relapse remains a leading cause of death after allogeneic hematopoietic cell transplantation (HCT) for patients with high-risk leukemias. The potentially beneficial donor T cell-mediated graft-versus-leukemia (GVL) effect is often mitigated by concurrent graft-versus-host disease (GVHD). Providing T cells that can selectively target Wilms tumor antigen 1(More)
In spite of the recent advances in 3D shape measurement and geometry reconstruction, simultaneously achieving fast-speed and high-accuracy performance remains a big challenge in practice. In this paper, a 3D imaging and shape measurement system is presented to tackle such a challenge. The fringe-projection-profilometry-based system employs a number of(More)
Let (M,G, μ) be a Riemannian weakly symmetric space. Fix a base point x0 ∈ M and denote by H to be the compact isotropy subgroup of G at x0 . It is proven that L (H \G/H) is commutative, i.e. (G,H) is a Gelfand pair. This extends É. Cartan’s result for Riemannian symmetric spaces. Conversely, if (G,H) is a Riemannian weakly symmetric pair, then M = G/H can(More)
Recent trends in distributed real-time and embedded (DRE) systems motivate the development of tactical information management capabilities that ensure the right information is delivered to the right place at the right time to satisfy quality of service (QoS) requirements in heterogeneous environments. A promising approach to building and evolving largescale(More)