Hideyuki Horike

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BACKGROUND Recent studies showed that angiotensin II type 1 receptor blocker (ARB) slows progression of chronic renal disease in patients with type 2 diabetes, regardless of changes in blood pressure. We showed that the imbalance of nitric oxide (NO) and reactive oxygen species (ROS) due to endothelial NO synthase (eNOS) uncoupling contributed to renal(More)
have been no investigations on the roles of NO and BH 4 in CAPD. Therefore, we measured both NO and BH 4 concentrations in spent dialysates of CAPD patients to investigate the relation between the two. The NO concentration was measured by an NO sensor [6, 12] and BH 4 and BH 2 concentrations were measured fluoromet-rically by the HPLC-based method [13].(More)
Lipoprotein glomerulopathy (LPG) is a rare glomerulopathy caused by lipoprotein thrombi. In almost all cases of LPG, several apolipoprotein (apo) E mutations were reported. Here, we present a case of LPG caused by a novel mutation that we named ApoE2 Kurashiki, which substitutes arginine with proline at apoE codon 158. ApoE2 polymorphism is well known for(More)
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