Hideyuki Hirasawa

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INTRODUCTION NO is synthesized by three different NO synthase (NOS) isoforms, including neuronal (nNOS), inducible (iNOS) and endothelial NOS (eNOS). The roles of NO in bone metabolism have been extensively investigated in pharmacological studies and in studies with NOS isoform-deficient mice. However, because of the nonspecificity of agents and(More)
It is assumed that there are systemic changes in mineral metabolism during fracture healing that may cause a predisposition to sequential fractures in osteoporotic patients who suffered from previous fractures. Initial therapies for patients with osteoporotic fractures are important to prevent disabilities in daily life consequent to bone and muscle(More)
We tested the hypothesis that signaling of parathyroid hormone (PTH) facilitates osteoclastogenesis in bone marrow cells after immobilization, thereby reducing trabecular bone volume. We performed histomorphometric analyses in immobilized limbs after right sciatic neurectomy (IM) and in the contralateral limbs after sham surgery (M). Mice underwent(More)
This study aimed to clarify the association between abnormal Wnt signaling and the cause of idiopathic carpal tunnel syndrome (ICTS) and whether an association exists between Wnt signaling and cell proliferation in the flexor tenosynovium. The subjects included nine patients with ICTS; the controls were nine patients with distal radius fractures without any(More)
Cellular perturbations such as stress to the endoplasmic reticulum induce an integrated stress response, which activates phosphorylation of eIF2alpha and leads to alleviation of cellular injury or apoptosis. This study investigated the role of mechanical stimulation in the regulation of eIF2alpha and cell death. Mechanical stimulation was applied to mouse(More)
UNLABELLED Osteoblast apoptosis increased in the tibias of apoE(-/-) mice fed with a high-fat diet, decreasing bone formation. The expression of p53 mRNA in marrow adherent cells increased. LDL or oxidized LDL increased apoptosis in the calvarial cells of apoE(-/-) mice. The increase in p53-mediated apoptosis is apparently related to a high-fat diet-induced(More)
Carpal tunnel syndrome (CTS) is the most frequently reported entrapment neuropathy; however, the exact pathological mechanism of CTS remains unknown. In a recent paper published in the Journal of Orthopaedic Research, we investigated the associations between Wnt signaling and the etiology of idiopathic CTS (ICTS). We compared the expression levels of genes(More)
The high-temperature oxidation behavior of Ti­(6­36)mass%Al alloys and Ti­(4­15)mass%V alloys has been investigated in a temperature range of 1123 to 1273K in air. A kinetic study of the oxidation has been also carried out in Ti­6mass%Al alloy and Ti­4mass%V alloy. The growth rate of oxides of Ti­V alloys is larger than that of Ti­Al alloys. The oxidation(More)
Makoto Abe Masahiro Abe Haruhiko Akiyama Norio Amizuka Kazuhiro Aoki Takatoshi Aoki Kiyoshi Aoyagi Nobuhito Araki Hiroshi Asahara Izumi Asahina Giampiero I. Baroncelli David B. Burr Jianquan Chen Po-Quang Chen Ching-Lung Cheung Hyung Jin Choi Naoyuki Chosa Ho-Yeon Chung Feng Dai Artemis Doulgeraki Kosuke Ebina Itsuro Endo Naoto Endo Yoichi Ezura José Luis(More)
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