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Aneurysmal subarachnoid hemorrhage: pathobiology, current treatment and future directions.

• Joseph C Serrone, Hidetsugu Maekawa, Mardjono Tjahjadi, Juha Hernesniemi
• Expert review of neurotherapeutics
• 2015

Aneurysmal subarachnoid hemorrhage is the most devastating form of stroke. Many pathological mechanisms ensue after cerebral aneurysm rupture, including hydrocephalus, apoptosis of endothelial cells… (More)

Presigmoid Approach to Vertebrobasilar Artery Aneurysms: A Series of 31 Patients and Review of the Literature.

• Mardjono Tjahjadi, M Niemelä, +8 authors J Hernesniemi
• World neurosurgery
• 2016

OBJECTIVE The presigmoid approach can be used to treat vertebrobasilar artery aneurysms when circumstances require more operative exposure. High morbidity and mortality in these cases have been… (More)

Bazedoxifene, a selective estrogen receptor modulator, reduces cerebral aneurysm rupture in Ovariectomized rats

• Hidetsugu Maekawa, Yoshiteru Tada, +6 authors Shinji Nagahiro
• Journal of Neuroinflammation
• 2017

Estrogen deficiency is thought to be responsible for the higher frequency of aneurysmal subarachnoid hemorrhage in post- than premenopausal women. Estrogen replacement therapy appears to reduce this… (More)

Recurrent periventricular hemorrhage in cerebral proliferative angiopathy: Case report.

• Hidetsugu Maekawa, Aiko Terada, +4 authors Timo Krings
• Interventional neuroradiology : journal of…
• 2018

Cerebral proliferative angiopathy (CPA) is a rare vascular lesion. Bleeding from CPA is uncommon, but the risk of rebleeding is high once it bleeds. We describe a case of CPA with multiple intra- and… (More)

Factors Determining Surgical Approaches to Basilar Bifurcation Aneurysms and Its Surgical Outcomes.

• Mardjono Tjahjadi, Juri Kivelev, +5 authors J Hernesniemi
• Neurosurgery
• 2016

BACKGROUND The basilar bifurcation aneurysm (BBA) is still considered to be one of the most challenging aneurysms for micro- and endovascular surgery. Classic surgical approaches, such as… (More)

The role of estrogen on the pathology of cerebral aneurysms.

• Hidetsugu Maekawa, Joseph C Serrone, Mardjono Tjahjadi, J Hernesniemi
• Expert review of neurotherapeutics
• 2016

INTRODUCTION Epidemiological studies suggest that postmenopausal estrogen deficiency is responsible for the increased risk of aneurysmal subarachnoid hemorrhage, while menopausal hormone therapy is… (More)

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