Hidetoshi Nakagawa

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Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) and its associated receptors (TRAIL-R/TR) are attractive targets for cancer therapy because TRAIL induces apoptosis in tumor cells through TR while having little cytotoxicity on normal cells. Therefore, many agonistic monoclonal antibodies (mAbs) specific for TR have been produced, and(More)
Antigen-specific T cell therapy, or T cell receptor (TCR) gene therapy, is a promising immunotherapy for infectious diseases and cancers. However, a suitable rapid and direct screening system for antigen-specific TCRs is not available. Here, we report an efficient cloning and functional evaluation system to determine the antigen specificity of TCR cDNAs(More)
AIM Inflammation plays a critical role in cancer. The aim of the present study was to investigate the impact of neutrophil to lymphocyte ratio (NLR) on patients with advanced hepatocellular carcinoma (HCC) treated with hepatic arterial infusion chemotherapy (HAIC). METHODS We retrospectively evaluated 266 patients with advanced HCC treated with HAIC(More)
Dual-rail logic circuit elements based on rapid single-flux-quantum (RSFQ) technology have been designed and simulated. The proposed circuits can operate asynchronously, since dual-rail data include timing information in themselves. Therefore dual-rail logic scheme has a possibility of solving some problems of RSFQ circuits with flow clocking, which would(More)
A high temperature resistant joint technology for bonding SiC power devices is developed using a transient liquid phase sintering (TLPS) process with a paste containing Cu and Sn powders with the size less than 15&#x03BC;m. The SiC devices are bonded to the Si<sub>3</sub>N<sub>4</sub>/Cu/Ni(P) substrate with the TLPS process at 260&#x00B0;C in a(More)
We demonstrate 10-Gb/s/ch operations of high-density, low-cost 12-channel optical modules for optical interconnections. These optical modules that we developed are designed to be pluggable into cards with an electrical connector. These pluggable modules will enable cards to be manufactured much more easily since they allow the manufacturing processes of(More)
Plasma process-induced recess structure and the latent defect site density are quantitatively evaluated in detail by using optical and electrical methods combined with a classical molecular dynamics (MD) simulation. A new framework is proposed and demonstrated for predicting the relationship between plasma process parameters and MOSFET performance(More)
To investigate central serotonergic (5-HT) and dopaminergic (DA) actions of lisuride, the discriminative properties of lisuride (0.05mg/kg, i.p.) in rats were investigated, in addition to the radioligand binding of the compound to 5-HT and DA receptor subtypes. Lisuride was found to possess high affinities for 5-HT(1A) receptor sites (Ki=0.5nM) and D(2)(More)
Drug discrimination training with terguride, a 9, 10-transdihydrogenated derivative of lisuride, was carried out using a two-lever food-reinforced procedure (FR 10) in rats, to investigate its influence on central dopaminergic (DA) and serotonergic (5-HT) functions. The terguride (0.05mg/kg, i.p.) discrimination was established within 64 +/- 5 training(More)
For broadband data communication between Josephson and CMOS digital systems, amplification of small Josephson-output signals and synchronization between the systems are important issues. We present an interface circuit for a Josephson-CMOS hybrid digital system. The interface circuit consists of a parallel-in-parallel-out (PIPO) circuit and built-in(More)