Hidetoshi Ishibashi

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Earlier work has suggested that Fyn tyrosine kinase plays an important role in synaptic plasticity. To understand the downstream targets of Fyn signaling cascade in neurons, we generated transgenic mice expressing either a constitutively activated form of Fyn or native Fyn in neurons of the forebrain. Transgenic mice expressing mutant Fyn exhibited higher(More)
When humans repeatedly use a tool, our body image alters until the tool finally becomes a part or an extension of the body. This alteration of body image perhaps results from re-integration of somatosensory and visual signals. We trained Japanese monkeys to use a rake-shaped tool to retrieve a distant food pellet, then used a novel tissue-sampling method to(More)
1. Synaptophysin is responsible for the cycling of the synaptic vesicles containing the neurotransmitter, and it can be phosphorylated. 2. This study examined whether repeated whisker stimulation alters the expression of synaptophysin mRNA in the rat barrel cortex, and found induced expression of synaptophysin mRNA in the contralateral barrel cortex(More)
To examine whether joint attention enables Japanese monkeys to imitate human actions, we presented an oral action and manual actions directed towards targets to three monkeys who had joint attention through communicative eye-gaze and pointing gestures and to one monkey who had incomplete joint attention and who had acquired imperative pointing but not the(More)
Learning but not execution of tool-use induced expression of brain-derived neurotrophic factor (BDNF). The expression was highest in the anterior bank of the intraparietal sulcus, especially in the region posteriorly adjacent to the somatosensory shoulder and forearm region in area 3b, suggesting that BDNF plays a role in altering the body image of the hand(More)
Social interactions are a fundamental aspect of human and animal behavior. Although neuroimaging and other non-invasive methods have progressed recently, the neurobiology of social behavior requires the use of animal models. Here, we introduced a multi-behavior parameter integration method and applied it to female-male interaction of adult common marmosets(More)
The amygdala plays an important role in the processing of emotional events. This information processing is altered by development, but little is known about the development of electrophysiological properties of neurons in the amygdala. We studied the postnatal development of electrophysiological properties of neurons in the basolateral amygdala (BLA) of the(More)
Age-associated neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and the polyglutamine (polyQ) diseases, are becoming prevalent as a consequence of elongation of the human lifespan. Although various rodent models have been developed to study and overcome these diseases, they have limitations in their translational research(More)
Profiles of recombinant adeno-associated virus (rAAV)-mediated transduction show interspecies differences for each AAV serotype. Robust long-term transgene expression is generally observed in rodents, whereas insufficient transduction is seen in animals with more advanced immune systems. Non-human primates, including the common marmoset, could provide(More)
We found that mice carrying constitutively active Fyn tyrosine kinase show low levels of spontaneous locomotor activity and that this activity increases when the mice are treated with the NMDA receptor antagonist MK-801. These findings indicate that the tyrosine phosphorylation of the NMDA receptors by Fyn participates in the control of locomotor activity.