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Proteomic identification of a PSF/p54nrb heterodimer as RNF43 oncoprotein‐interacting proteins
RNF43 is an oncogenic RING finger protein overexpressed in colorectal cancer. To dissect its biological functions, we explored RNF43‐interacting proteins by pull‐down assay and MS. We identified aExpand
Proteomic Comparison of the Secreted Factors of Mesenchymal Stem Cells from Bone Marrow, Adipose Tissue and Dental Pulp
Mesenchymal stem cells (MSCs) have therapeutic potential in various diseases, including myocardial infarction. Recently, the importance of the therapeutic effects of secreted factors from MSCs isExpand
Paraoxonase 1 as a Major Bioactivating Hydrolase for Olmesartan Medoxomil in Human Blood Circulation: Molecular Identification and Contribution to Plasma Metabolism
Olmesartan medoxomil (OM) is a prodrug-type angiotensin II type 1 receptor antagonist. The OM-hydrolyzing enzyme responsible for prodrug bioactivation was purified from human plasma throughExpand
Bioactivation of loxoprofen to a pharmacologically active metabolite and its disposition kinetics in human skin
Loxoprofen (LX) is a prodrug‐type non‐steroidal anti‐inflammatory drug which is used not only as an oral drug but also as a transdermal formulation. As a pharmacologically active metabolite, theExpand
Identification of a Metabolizing Enzyme in Human Kidney by Proteomic Correlation Profiling
Molecular identification of endogenous enzymes and biologically active substances from complex biological sources remains a challenging task, and although traditional biochemical purification isExpand
Identification of activating enzymes of a novel FBPase inhibitor prodrug, CS-917
CS‐917 (MB06322) is a selective small compound inhibitor of fructose 1,6‐bisphosphatase (FBPase), which is expected to be a novel drug for the treatment of type 2 diabetes by inhibitingExpand
Electrical equivalent circuit parameters for montmorillonite clay film-coated quartz crystal oscillators in contact with air, moisture and electrolyte solutions
Abstract The piezoelectric admittance measurements of the quartz crystal oscillators with and without a montmorillonite clay coating have been carried out over the frequency range covering the areaExpand
Enzymatic kinetics regarding reversible metabolism of CS-0777, a sphingosine 1-phosphate receptor modulator, via phosphorylation and dephosphorylation in humans
Abstract 1. CS-0777, a candidate compound for autoimmune diseases, becomes phosphorylated active metabolite, M1, by fructosamine 3-kinase (FN3K), FN3K-related protein (FN3K-RP); and M1 is revertedExpand
Perturbation-Based Proteomic Correlation Profiling as a Target Deconvolution Methodology.
Molecular target identification of small molecules, so-called target deconvolution, is a major obstacle to phenotype-based drug discovery. Here, we developed an approach called perturbation-basedExpand
Identification of antibody-interacting proteins that contribute to the production of recombinant antibody in mammalian cells
Protein folding and assembly processes are essential for antibody secretion; however, the endogenous proteins involved in these processes remain largely unknown. Therefore, except for some well-knownExpand