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Proteomic identification of a PSF/p54nrb heterodimer as RNF43 oncoprotein‐interacting proteins
Proteomic identification of RNF43‐associated proteins sheds light on its dynamic interaction network in nuclear events and reveals that co‐expression of PSF relocates R NF43 from the nuclear periphery to the nucleoplasm.
Proteomic Comparison of the Secreted Factors of Mesenchymal Stem Cells from Bone Marrow, Adipose Tissue and Dental Pulp
The secreted protein profiles of MSCs derived from bone marrow, adipose tissue and dental pulp are uncovered and it is revealed that common factors strongly relate to tissue regeneration pathways such as angiogenesis, migration, and inflammatory response.
Bioactivation of loxoprofen to a pharmacologically active metabolite and its disposition kinetics in human skin
- R. Sawamura, Hidetaka Sakurai, T. Izumi
- Biology, ChemistryBiopharmaceutics & drug disposition
- 1 September 2015
This is the first report in which LX is bioactivated to the trans‐OH form in human skin by CBR1, and it was found that no unknown metabolites were generated in the human in vitro skin.
Paraoxonase 1 as a Major Bioactivating Hydrolase for Olmesartan Medoxomil in Human Blood Circulation: Molecular Identification and Contribution to Plasma Metabolism
PON1 is identified as the OM-bioactivating hydrolase in human plasma on a molecular basis and it is demonstrated that PON1, but not albumin, plays a major role in OM bioactivation inhuman plasma.
Identification of a Metabolizing Enzyme in Human Kidney by Proteomic Correlation Profiling
- Hidetaka Sakurai, K. Kubota, Shin-ichi Inaba, K. Takanaka, A. Shinagawa
- BiologyMolecular & Cellular Proteomics
- 14 May 2013
An improved workflow of proteomic correlation profiling is applied to a drug metabolizing enzyme and the identification of ALPL as CS-0777-P phosphatase was strongly supported by a recombinant protein, and contribution of the enzyme in human kidney extract was validated by immunodepletion and a specific inhibitor.
Identification of activating enzymes of a novel FBPase inhibitor prodrug, CS-917
- K. Kubota, Shin-ichi Inaba, A. Shinagawa
- Biology, ChemistryPharmacology research & perspectives
- 4 May 2015
This study biochemically purified the CS‐917 esterase activity in monkey small intestine and liver and identified sphingomyelin phosphodiesterase, acid‐like 3A, as an R‐134450 phosphoramidase, which has not been reported to have any enzyme activity.
Perturbation-Based Proteomic Correlation Profiling as a Target Deconvolution Methodology.
Novel LCAT (Lecithin:Cholesterol Acyltransferase) Activator DS-8190a Prevents the Progression of Plaque Accumulation in Atherosclerosis Models
- M. Sasaki, Mina Delawary, K. Kubota
- BiologyArteriosclerosis, thrombosis, and vascular…
- 22 October 2020
This compound proves that a small-molecule direct LCAT activator can achieve HDL-C elevation in monkey and reduction of atherosclerotic lesion area with enhanced HDL function in rodent.
Electrical equivalent circuit parameters for montmorillonite clay film-coated quartz crystal oscillators in contact with air, moisture and electrolyte solutions
Enzymatic kinetics regarding reversible metabolism of CS-0777, a sphingosine 1-phosphate receptor modulator, via phosphorylation and dephosphorylation in humans
- Shin-ichi Inaba, Maki Yamaguchi-Goto, T. Izumi
- Biology, ChemistryXenobiotica; the fate of foreign compounds in…
- 1 March 2018
FN3K-RP is expected to take a prominent role in the phosphorylation of CS-0777 in human erythrocytes and dephosphorylation was observed in all ALPs and human tissue microsomes examined, with a similar affinity towards M1 among them.