Hidero Akiyama

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Propofol (PF), a highly lipophilic anesthetic, has several desirable properties, such as the rapid onset and cessation of its effects upon intravenous infusion. In this study, the transdermal absorption of PF was investigated with the aim of the development of an alternative route of administration. PF solutions containing isopropyl myristate (IPM), ethanol(More)
To develop a transdermal dosage form of propofol (PF), in vitro skin permeability and in vivo absorbability of PF were investigated in rats, and the effectiveness of enhancers on the transdermal delivery of PF was estimated. Propylene glycol (PG), isopropyl myristate and macrogol were used as co-solvent type enhancers. L(-)-Menthol (MEN), D(+)-limonene,(More)
An implant controlled-release system for protein drug delivery based on a polyion complex device composed of chitosan (CS) and sodium hyaluronate (HA) was investigated. The conditions which generated the greatest amount of the polyion solid complex were studied to ascertain the formation of polyion complex between CS and HA. The greatest amount of the(More)
cally as it 1) has a rapid onset and cessation of effect upon intravenous infusion, 2) accumulates little and induces a brief but profound anesthesia, 3) maintains a level in the circulation similar to the levels achieved by inhalation anesthetics. Since PF is formulated as an intravenous emulsion containing soybean oil and egg yolk lecithin, it causes(More)
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