Hideo Watanabe

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Lineage-survival oncogenes are activated by somatic DNA alterations in cancers arising from the cell lineages in which these genes play a role in normal development. Here we show that a peak of genomic amplification on chromosome 3q26.33 found in squamous cell carcinomas (SCCs) of the lung and esophagus contains the transcription factor gene SOX2, which is(More)
This paper proposes a new paradigm for sentiment analysis: translation from text documents to a set of sentiment units. The techniques of deep language analysis for machine translation are applicable also to this kind of text mining task. We developed a high-precision sentiment analysis system at a low development cost, by making use of an existing(More)
Tissue-specific differentiation programs become dysregulated during cancer evolution. The transcription factor Nkx2-1 is a master regulator of pulmonary differentiation that is downregulated in poorly differentiated lung adenocarcinoma. Here we use conditional murine genetics to determine how the identity of lung epithelial cells changes upon loss of their(More)
Digalactosyldiacylglycerol (DGDG) is a typical membrane lipid of oxygenic photosynthetic organisms. Although DGDG synthase genes have been isolated from plants, no homologous gene has been annotated in the genomes of cyanobacteria and the unicellular red alga Cyanidioschyzon merolae. Here we used a comparative genomics approach and identified a(More)
In this paper, we describe a system and methods for finding structural correspondences from the paired dependency structures of a source sentence and its translation in a target language. The system we have developed finds word correspondences first, then finds phrasal correspon(tences based on word correspondences. We have also developed a GUI system with(More)
Lung squamous cell carcinoma (SCC) is a deadly disease for which current treatments are inadequate. We demonstrate that biallelic inactivation of Lkb1 and Pten in the mouse lung leads to SCC that recapitulates the histology, gene expression, and microenvironment found in human disease. Lkb1;Pten null (LP) tumors expressed the squamous markers KRT5, p63 and(More)
Alterations in the processing of the genetic information in carcinogenesis result from stable genetic mutations or epigenetic modifications. It is becoming clear that nucleosomal histones are central to proper gene expression and that aberrant DNA methylation of genes and histone methylation plays important roles in tumor progression. To date, several(More)
The transfer phase in machine translation (MT) systems has been considered to be more complicated titan analysis and generation~ since it is inherently a conglomeration of individual lexical rules. Currently some at tempts are being made to use case-based reasoning in machine translation, that is, to make decisions on the basis of translation examples at(More)
This paper describes a system for finding phrasal translation correspondences from parallel parsed corpus that are collections paired English and Japanese sentences. First, the system finds phrasal correspondences by Japanese-English translation dictionary consultation. Then, the system finds correspondences in remaining phrases by using sentences(More)
IMPORTANCE Evidence indicates a complex link between gut microbiome, immunity, and intestinal tumorigenesis. To target the microbiota and immunity for colorectal cancer prevention and therapy, a better understanding of the relationship between microorganisms and immune cells in the tumor microenvironment is needed. Experimental evidence suggests that(More)