Hideo Nakanishi

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PURPOSE To investigate the contribution of two single-nucleotide polymorphisms (SNPs) of the lysyl oxidase-like 1 (LOXL1) gene, recently shown to be associated with exfoliation syndrome (XFS) and exfoliation glaucoma (XFG) in the Nordic population, to the occurrence of XFS and XFG in the Japanese population. DESIGN Case-control association study. (More)
OBJECTIVE To evaluate the appearance of the optic nerve head and lamina cribrosa in patients with glaucoma using spectral/Fourier-domain optical coherence tomography (SD-OCT) and to test for a correlation between lamina cribrosa thickness measured on SD-OCT images and visual field loss. DESIGN Observational case series. PARTICIPANTS We evaluated 52 eyes(More)
PURPOSE To seek an association in Japanese individuals between the CFH polymorphisms Y402H and I62V and the ARMS2 polymorphism A69S and age-related macular degeneration (AMD) or its three subtypes: typical (t)AMD, polypoidal choroidal vasculopathy (PCV), and retinal angiomatous proliferation (RAP). METHODS The three polymorphisms were genotyped in a(More)
BACKGROUND Typical exudative age-related macular degeneration (AMD) and polypoidal choroidal vasculopathy (PCV) are two of the major macular diseases found in Asians. Although genomic studies have shown a contribution by CFH and LOC387715/HTRA1 polymorphisms to the development of these two diseases, the correlation of the clinical phenotypes to these(More)
PURPOSE To investigate whether there are associations of genetic variations in chromosome 15q14 and 15q25, recently shown to confer risk of refractive error and myopia in Caucasians, with high myopia in Japanese. METHODS A total of 1125 unrelated Japanese patients with high myopia and two independent control groups were evaluated (366 cataract patients(More)
The purpose of the present study was to evaluate the mechanical durability of a zirconia/alumina nanocomposite stabilized with cerium oxide (Ce-TZP/Al(2)O(3) nanocomposite) in comparison to yttria-stabilized tetragonal zirconia polycrystals (Y-TZP) and discuss its application on ceramic dental restorations. The disk-shaped specimens of both materials were(More)
To compare the genomic contribution of the ARMS2/HTRA1 region of chromosome 10q26 to typical neovascular age-related macular degeneration (nAMD) (also known as typical exudative AMD) and to polypoidal choroidal vasculopathy (PCV) DNA samples were prepared from 84 patients with typical nAMD, 181 patients with PCV, and 276 control participants. All of the 18(More)
PURPOSE To detect the prognostic factors associated with initial reattachment after primary pars plana vitrectomy (PPV) with gas tamponade for retinal detachment attributable to macular hole (MHRD). DESIGN Retrospective, multicenter, interventional case series. METHODS This study included 49 eyes of 48 patients with MHRD in high myopia (axial length(More)
Myopia is one of the most common ocular disorders worldwide. Pathological myopia, also called high myopia, comprises 1% to 5% of the general population and is one of the leading causes of legal blindness in developed countries. To identify genetic determinants associated with pathological myopia in Japanese, we conducted a genome-wide association study,(More)
PURPOSE To assess detached macula in rhegmatogenous retinal detachment by using spectral-domain optical coherence tomography. METHODS This retrospective study included 15 eyes of 15 patients with macula-off rhegmatogenous retinal detachment and 16 eyes of 16 patients with acute central serous chorioretinopathy. These patients were examined with a(More)